One-pot highly stereoselective reduction of β-keto amides to syn-γ-aminols
One-pot highly stereoselective reduction of β-keto amides to syn-γ-aminols
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DOI：
10.1016/s0040-4039(01)01904-9
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发表时间：
2001-12-10
影响因子：
1.8
通讯作者：
Sambri, L
中科院分区：
文献类型：
--
作者：
Bartoli, G;Bosco, M;Sambri, L
在四氯化钛存在下，硼烷/四氢呋喃络合物能以良好的产率和高的非对映选择性将2-甲基-3-氧代酰胺还原为相应的顺式氨基醇。使用硼烷/二甲基硫醚代替BH 3/THF允许部分还原成顺式-β-羟基酰胺。(C)2001爱思唯尔科技有限公司版权所有。
In the presence of titanium tetrachloride, the borane/tetrahydrofuran complex can reduce 2-methyl-3-oxoamides into the corresponding syn-aminols in good yields and high diastereoselectivity. The use of borane/dimethyl sulfide instead of BH3/THF allows a partial reduction to syn-beta -hydroxyamides. (C) 2001 Elsevier Science Ltd. All rights reserved.