Anatomy of a songbird basal ganglia circuit essential for vocal learning and plasticity.
Anatomy of a songbird basal ganglia circuit essential for vocal learning and plasticity.
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DOI：
10.1016/j.jchemneu.2009.07.003
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发表时间：
2010-03
影响因子：
2.8
通讯作者：
Perkel DJ
中科院分区：
文献类型：
--
作者：
Gale SD;Perkel DJ
鸣禽的发声学习需要一个解剖上离散的、功能上专用的回路，称为前脑前脑通路(AFP)。AFP与哺乳动物的皮质-基底节-丘脑-皮质环同源。这条通路的基底节部分，X区，有许多哺乳动物纹状体和苍白球的特征，包括细胞类型和连接性。AFP在根本上也偏离了哺乳动物的基底节环路。此外，X区的微电路、神经调节剂的作用和功能仍不清楚。阐明AFP的哺乳动物样特征和独特特征促进发声学习的机制有助于更广泛地理解基底节环路的感觉运动功能。
Vocal learning in songbirds requires an anatomically discrete and functionally dedicated circuit called the anterior forebrain pathway (AFP). The AFP is homologous to cortico-basal ganglia-thalamo-cortical loops in mammals. The basal ganglia portion of this pathway, Area X, shares many features characteristic of the mammalian striatum and pallidum, including cell-types and connectivity. The AFP also deviates from mammalian basal ganglia circuits in fundamental ways. In addition, the microcircuitry, role of neuromodulators, and function of Area X are still unclear. Elucidating the mechanisms by which both mammalian-like and unique features of the AFP contribute to vocal learning may help lead to a broad understanding of the sensorimotor functions of basal ganglia circuits.