Starvation in the rat. I. Effect of age and obesity on organ weights, RNA, DNA, and protein.
Starvation in the rat. I. Effect of age and obesity on organ weights, RNA, DNA, and protein.
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大鼠饥饿。
DOI：
10.1152/ajpendo.1980.239.4.e269
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Ruderman,NB
中科院分区：
文献类型：
--
作者：
Goodman,MN;Ruderman,NB
以往的研究表明，肥胖的人适应长期饥饿与身体蛋白质的保护。在试图描绘负责这种适应的生化和激素变化，饥饿的影响进行了研究，在不同的能力，以生存的快速和保存蛋白质的大鼠。通过脂肪喂养导致肥胖的16周大大鼠在饥饿中存活了25-30天，而16周大的对照组存活了11-12天，8周大的对照组存活了6-7天。饥饿降低肝脏重量，RNA和蛋白质在所有三个组的快速早期。在心脏，伸趾长肌和一些其他器官的RNA，蛋白质和重量的下降发生得更慢，在16周龄的控制和肥胖大鼠的幅度较小。8周龄组心肌蛋白和RNA明显丢失。我们的结论是，16周龄的控制和肥胖大鼠能够更好地生存和保存器官蛋白质和RNA在长期饥饿比年轻的大鼠。这在多大程度上反映了年龄的差异以及肥胖的差异仍有待确定。
Previous studies have shown that obese man adapts to prolonged starvation with a conservation of body protein. In an attempt to delineate the biochemical and hormonal changes responsible for this adaptation, the effect of starvation was studied in rats with differing abilities to survive a fast and conserve protein. Sixteen-week-old rats made obese by fat feeding survived starvation for 25-30 dys, whereas 16-wk-old controls survived 11-12 days and the 8-wk-old controls for 6-7 days. Starvation decreased hepatic weight, RNA, and protein early in the fast in all three groups. In heart, the extensor digitorum longus muscle and some other organs decreases in RNA, protein, and weight occurred more slowly and were smaller in magnitude in the 16-wk-old control and obese rats. A pronounced loss of cardiac protein and RNA occurred in the 8-wk-old group. We conclude that 16-wk-old control and obese rats are better able to survive and conserve organ protein and RNA during prolonged starvation than younger rats. To what extent this reflects differences in the age and to what extent differences in adiposity remains to be determined.