SIRT6: Novel Mechanisms and Links to Aging and Disease.
SIRT6: Novel Mechanisms and Links to Aging and Disease.
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DOI：
10.1016/j.tem.2016.10.002
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Chua KF
中科院分区：
文献类型：
--
作者：
Tasselli L;Zheng W;Chua KF
SIRT6是Sirtuin家族中NAD+依赖的酶家族的成员之一，已经在染色质信号和基因组维护中发挥了作用。通过这些功能，SIRT6可以预防与衰老相关的疾病，包括代谢性疾病和癌症，并可以延长小鼠的寿命。最近几年的研究表明，SIRT6是一种具有多种底物和催化活性的复杂酶，并发现了SIRT6在维持生物体健康跨度方面的新功能。在这里，我们从四个方面对SIRT6生物学的新发现和模型进行综述：异染色质稳定和沉默、干细胞生物学、癌症的发生和发展以及代谢稳态的调节。我们讨论了这些发现对衰老和衰老相关疾病过程中的治疗干预的可能影响。
SIRT6, a member of the Sirtuin family of NAD+-dependent enzymes, has established roles in chromatin signaling and genome maintenance. Through these functions, SIRT6 protects against aging-associated pathologies including metabolic disease and cancer, and can promote longevity in mice. Research from the last few years has revealed that SIRT6 is a complex enzyme with multiple substrates and catalytic activities, and uncovered novel SIRT6 functions in maintenance of organismal health span. Here, we review these new discoveries and models of SIRT6 biology in four areas: heterochromatin stabilization and silencing, stem cell biology, cancer initiation and progression, and regulation of metabolic homeostasis. We discuss possible implications of these findings for therapeutic interventions in aging and aging-related disease processes.