ELECTROENCEPHALOGRAPHIC CHANGES WITH AGE IN MALE MICE
ELECTROENCEPHALOGRAPHIC CHANGES WITH AGE IN MALE MICE
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DOI：
10.1159/000212027
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发表时间：
1975-01-01
期刊：
影响因子：
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通讯作者：
ELIAS, MF
中科院分区：
文献类型：
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作者：
ELEFTHERIOU, BE;ZOLOVICK, AJ;ELIAS, MF
在 DBA/2J 和 C57BL/6J 品系的老年雄性小鼠中记录了脑电图 (EEG) 变化，通过清醒状态、慢波睡眠 (SWS)、快速眼动 (REM) 模式和 REM/总睡眠比率来测量。结果表明，随着年龄的增长，两种品系的清醒状态均显着增加，同时 SWS 显着降低，尽管这些变化在 DBA/2J 小鼠中比 C57BL/6J 小鼠更为明显。具有相当重要意义的是，DBA/2J 品系小鼠在 23.5 个月大时缺乏快速眼动睡眠。基于这些发现，得出的结论是菌株 DBA/2J 老化速度明显快于 C57BL/6J。两种菌株之间的衰老差异强调需要对衰老的遗传方面进行更多研究。
Electroencephalographic (EEG) changes, as measured by the awake state, slow-wave sleep (SWS), rapid-eye movement (REM) patterns and ratio of REM/total sleep, were recordered in aging male mice of DBA/2J and C57BL/6J strains. Results indicate that there is a significant increase in the awake state accompanied by significant decrease in SWS with advancing age for both strains, although these changes appear more pronounced in DBA/2J mice than C57BL/6J mice. Of considerable significance is the finding that REM sleep is absent in mice of DBA/2J strain at 23.5 months of age. Based on these findings, the conclusion was reached that strain DBA/2J ages significantly faster than C57BL/6J. The difference in aging between the two strains emphasizes the need for additional studies dealing with genetic aspects of aging.