Genome sequence and analysis of the tuber crop potato
Genome sequence and analysis of the tuber crop potato
复制标题
块茎作物马铃薯基因组序列与分析
DOI：
10.1038/nature10158
复制
发表时间：
2011-07-14
期刊：
影响因子：
64.8
通讯作者：
Visser, Richard G. F.
中科院分区：
文献类型：
--
作者：
Xu, Xun;Pan, Shengkai;Visser, Richard G. F.
马铃薯（Solanum tuberosum L.）是世界上最重要的非粮食作物，对全球粮食安全至关重要。它是克隆繁殖，高度杂合，同源四倍体，并遭受急性近交衰退。在这里，我们使用一个纯合的双单倍体马铃薯克隆序列和组装86%的844兆基因组。我们预测了39，031个蛋白质编码基因，并提供了至少两个基因组重复事件的证据，表明古多倍体起源。作为星号的第一个基因组序列，马铃薯基因组揭示了这个大型被子植物分支特有的2，642个基因。我们还对一个杂合二倍体克隆进行了测序，结果表明基因存在/缺失变异和其他潜在的有害突变经常发生，并且可能是近亲繁殖抑郁症的原因。基因家族的扩展、组织特异性表达和基因向新途径的募集促进了块茎发育的进化。马铃薯基因组序列为这种重要作物的遗传改良提供了平台。
Potato (Solanum tuberosum L.) is the world's most important non-grain food crop and is central to global food security. It is clonally propagated, highly heterozygous, autotetraploid, and suffers acute inbreeding depression. Here we use a homozygous doubled-monoploid potato clone to sequence and assemble 86% of the 844-megabase genome. We predict 39,031 protein-coding genes and present evidence for at least two genome duplication events indicative of a palaeopolyploid origin. As the first genome sequence of an asterid, the potato genome reveals 2,642 genes specific to this large angiosperm clade. We also sequenced a heterozygous diploid clone and show that gene presence/absence variants and other potentially deleterious mutations occur frequently and are a likely cause of inbreeding depression. Gene family expansion, tissue-specific expression and recruitment of genes to new pathways contributed to the evolution of tuber development. The potato genome sequence provides a platform for genetic improvement of this vital crop.