Neurological condition in 18-month-old children perinatally exposed to polychlorinated biphenyls and dioxins
Neurological condition in 18-month-old children perinatally exposed to polychlorinated biphenyls and dioxins
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DOI：
10.1016/0378-3782(95)01674-0
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发表时间：
1995-10-02
影响因子：
2.5
通讯作者：
Touwen, BCL
中科院分区：
文献类型：
--
作者：
Huisman, M;KoopmanEsseboom, C;Touwen, BCL
为了确定产前和母乳介导的多氯联苯（PCBs）和二恶英暴露是否会影响神经发育，对418个月大的荷兰儿童的神经系统最佳性进行了评估。一半的婴儿母乳喂养，另一半母乳喂养。脐带和母体血浆中的多氯联苯浓度被用作产前多氯联苯暴露的测量指标。为了测量出生后的暴露，对母乳和配方奶中的多氯联苯和二恶英同系物进行了测定。在调整协变量后，经胎盘多氯联苯暴露与18个月时的神经状况呈负相关。虽然通过护理转移的多氯联苯和二恶英的数量比通过胎盘转移的多氯联苯和二恶英的数量要多，但无法检测到哺乳期接触多氯联苯和二恶英的影响。我们甚至发现母乳喂养对运动的流畅性有有益的影响。我们得出结论，经胎盘PCB通道对18个月大的幼儿的神经系统状况有小的负面影响。
The neurological optimality of 418 Dutch children was evaluated at the age of 18 months, in order to determine whether prenatal and breast milk mediated exposure to polychlorinated biphenyls (PCBs) and dioxins affected neurological development, Half of the infants were breast-fed, the other half were formula-fed. PCB concentrations in cord and maternal plasma were used as a measure of prenatal exposure to PCBs. To measure postnatal exposure, PCB and dioxin congeners were determined in human milk and in formula milk. After adjusting for covariates, transplacental PCB exposure was negatively related to the neurological condition at 18 months. Although greater amounts of PCBs and dioxins are transferred via nursing than via placental passage, an effect of lactational exposure to PCBs and dioxins could not be detected. We even found a beneficial effect of breast-feeding on the fluency of movements. We conclude that transplacental PCB passage has a small negative effect on the neurological condition in 18-month-old toddlers.