Vitamin D concentration and its association with past, current and future depression in older men: The Health In Men Study
Vitamin D concentration and its association with past, current and future depression in older men: The Health In Men Study
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DOI：
10.1016/j.maturitas.2015.01.016
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发表时间：
2015-05-01
期刊：
影响因子：
4.9
通讯作者：
Flicker, Leon
中科院分区：
文献类型：
--
作者：
Almeida, Osvaldo P.;Hankey, Graeme J.;Flicker, Leon
背景：维生素D缺乏与晚年抑郁有关，但这种联系是否真的是因果关系尚不清楚。方法：观察性研究，对生活在西澳大利亚珀斯市区的3105名老年男性进行回顾性、横断面和前瞻性研究，研究维生素D浓度与抑郁情绪之间的关系。我们使用标准程序测量25-羟基维生素D的血浆浓度。过去的抑郁症是通过直接询问和使用行政卫生数据链接来确定的。老年人抑郁量表得分等于或大于7/15确定当前抑郁的存在。通过患者健康问卷（PHQ-9）评分>= 10或在6年随访期间（0.1-10.9年）通过行政健康数据链接确定事件性抑郁。结果：维生素D浓度
Background: Vitamin D deficiency has been associated with depression in later life, but it remains unclear whether this association is truly causal.Methods: Observational study examining the retrospective, cross-sectional-and prospective associations between vitamin D concentration and depressed mood in a community-derived sample of 3105 older men living in metropolitan Perth, Western Australia. We measured the plasma concentration of 25-hydroxyvitamin D using standard procedures. Past depression was ascertained by direct questioning and through the use of administrative health data linkage. A geriatric depression scale score equal or greater 7/15 established the presence of current depression. Incident depression was established by a patient health questionnaire (PHQ-9) score >= 10 or by administrative health data linkage during the 6-year follow up (range 0.1-10.9 years).Results: Vitamin D concentration