Inhibitory effects of Japanese apricot (Prunus mume Siebold et Zucc.; Ume) on Helicobacter pylori-related chronic gastritis
Inhibitory effects of Japanese apricot (Prunus mume Siebold et Zucc.; Ume) on Helicobacter pylori-related chronic gastritis
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DOI：
10.1038/ejcn.2010.70
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发表时间：
2010-07-01
影响因子：
4.7
通讯作者：
Ichinose, M.
中科院分区：
文献类型：
--
作者：
Enomoto, S.;Yanaoka, K.;Ichinose, M.
目的：我们研究日本杏（JA）摄入量与幽门螺杆菌相关的慢性萎缩性胃炎（CAG）之间的相关性。方法：进行问卷调查并检测血清抗幽门螺杆菌。在 1358 名无症状成年人中测量幽门螺杆菌 IgG 抗体。受试者被分为高摄入量组和低摄入量组。对68名非老年志愿者进行H. pylori相关CAG的组织学和血清学评估。结果：高摄入组和低摄入组之间H. pylori阴性率没有显着差异。高摄入量组的平均抗体滴度较低，但差异并不显着。当受试者按年龄分层时，基于 JA 摄入量的幽门螺杆菌感染率没有显着差异。在幽门螺杆菌阳性的非老年受试者中，高摄入组的抗体滴度显着较低（P = 0.041）。对 68 名志愿者进行的内窥镜组织活检显示，无论高摄入组的胃部位如何，幽门螺杆菌细菌载量和单核浸润均较少。在高摄入量组中，胃窦中性粒细胞浸润明显不那么明显，体萎缩也不那么广泛。使用血清 PG 水平进行的血清学评估也证实了这些组织病理学数据。结论：我们的研究结果强烈表明，JA 摄入通过抑制幽门螺杆菌感染和减少活动性粘膜炎症对 CAG 具有预防作用。欧洲临床营养杂志 (2010) 64, 714-719； doi:10.1038/ejcn.2010.70; 2010 年 6 月 2 日在线发布
Objectives: We investigated the correlation between Japanese apricot (JA) intake and Helicobacter pylori-related chronic atrophic gastritis (CAG).Methods: A questionnaire was administered and serum anti-H. pylori IgG antibodies measured in 1358 asymptomatic adults. The subjects were divided into high-intake and low-intake groups. Histological and serological evaluation of H. pylori-related CAG was performed in 68 non-elderly volunteers.Results: The H. pylori-negative rate did not differ significantly between the high-intake and low-intake groups. Mean antibody titers were lower in the high-intake group, but the difference was not significant. There was no significant difference in the rate of H. pylori infection on the basis of JA intake when subjects were stratified by age. Among H. pylori-positive non-elderly subjects, antibody titers were significantly lower in the high-intake group (P = 0.041). Endoscopic tissue biopsy from the 68 volunteers showed less H. pylori bacterial load and mononuclear infiltration irrespective of gastric site in the high-intake group. In the high-intake group, antral neutrophil infiltration was significantly less pronounced and corporal atrophy was less extensive. Serological evaluation using serum PG levels also confirmed these histopathological data.Conclusions: Our findings strongly indicate a preventive effect of JA intake on CAG by inhibiting H. pylori infection and reducing active mucosal inflammation. European Journal of Clinical Nutrition (2010) 64, 714-719; doi:10.1038/ejcn.2010.70; published online 2 June 2010