Polydimethylsiloxane (PDMS) irreversible bonding to untreated plastics and metals for microfluidics applications
Polydimethylsiloxane (PDMS) irreversible bonding to untreated plastics and metals for microfluidics applications
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DOI：
10.1063/1.5070136
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发表时间：
2019-08-01
期刊：
影响因子：
6.1
通讯作者：
Cecchini, Marco
中科院分区：
文献类型：
--
作者：
Agostini, Matteo;Greco, Gina;Cecchini, Marco
为了正确地将液体操作成微流控网络，设备的准确密封至关重要。聚二甲基硅氧烷(PDMS)具有成本低、制备简单快速、光学透明性好等优点，被广泛应用于微流控元件的制备。然而，PDMS的特点是表面能低，这使得它与许多衬底的结合不是微不足道的。提出了一种在未经处理的塑料和金属表面上进行PDMS微通道键合的通用技术。首先，用(3-氨丙基)三乙氧基硅烷(APTES)对PDMS表面进行官能化处理，进一步与环氧基团进行交联。然后，在PDMS-APTES表面涂覆诺兰光学粘合剂74(NOA74)。最后，将PDMS-APTES-NOA74与目标材料接触，并在紫外光下固化胶水。为了表征键合强度，制作了一套完整的PDMS-on-Gold微流控器件，并随注射压力的增加进行了测试。施加不同的液体和气体(氮气)，最高可达2巴，没有泄漏，这一值与报道的通过等离子体氧激活的标准玻璃-PDMS结合的值相当。随后，同样的技术被成功地复制到其他感兴趣的微流控非金属衬底上，即玻璃、聚甲基丙烯酸甲酯、聚苯乙烯、聚对苯二甲酸乙二酯、环烯烃共聚物，展示了其巨大的通用性和潜力，可用于但不限于微流控应用和LOC工程。(C)2019年作者(S)。
In order to properly manipulate liquids into microfluidic networks, an accurate sealing of the device is of paramount importance. Polydimethylsiloxane (PDMS) is ubiquitously used for fabricating microfluidic components, owing to its low cost, easy and fast fabrication, and optical transparency. However, PDMS is characterized by low surface energy, making its bonding to many substrates not trivial. Here is presented a versatile technique for PDMS microchannel bonding on untreated plastic and metal surfaces. First, the PDMS surface is functionalized with (3-aminopropyl) triethoxysilane (APTES) for further cross-linking with epoxy groups. Then, the PDMS-APTES surface is coated with Norland Optical Adhesive 74 (NOA74). Finally, the PDMS-APTES-NOA74 is put in contact with the target material and the glue is cured under a UV light. In order to characterize the bonding strength, a complete PDMS-on-gold microfluidic device is fabricated and tested with increasing injection pressures. Different liquids and a gas (nitrogen) are applied without leakage up to 2 bars, a value comparable to the one reported for the standard glass-PDMS bonding through plasma oxygen activation. The same technique is then successfully replicated with other nonmetallic substrates of interest for microfluidics, i.e., glass, poly(methyl methacrylate), polystyrene, polyethylene terephthalate, cyclic olefin copolymer, demonstrating its great versatility and potential for, but not limited to, microfluidic applications and LOC engineering. (C) 2019 Author(s).