Specific surface energies and dissolution behavior of aspirin crystal
Specific surface energies and dissolution behavior of aspirin crystal
复制标题
阿司匹林晶体的比表面能和溶解行为
DOI：
10.1248/cpb.33.4125
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发表时间：
1985
影响因子：
1.7
通讯作者：
K. Machida
中科院分区：
文献类型：
--
作者：
Yesook Kim;M. Matsumoto;K. Machida
通过使用从乙醇溶液中生长的大单晶来测定阿司匹林在蒸馏水中溶解时每个晶面的位移速度。研究发现阿司匹林的每个晶面都有自己的位移速度。那些晶体表面在水中和真空中的比表面能是根据一组原子-原子成对势函数计算的。晶体溶解时表面积减少的相对速率可以与表面能对溶剂极性的敏感性相关。
The displacement velocity of each crystalline face of aspirin on dissolution in distilled water was determined by using large single crystals grown from ethanolic solution. It was found that each crystalline face of aspirin has its own displacement velocity. The specific surface energies for those crystalline surfaces in water and in vacuo were calculated from a set of atom-atom pairwise potential functions. The relative rate of diminution of surface area on dissolution of the crystal can be correlated to the sensitivity of the surface energy to the polarity of the solvent.