Elevated cytokine expression in the orbitofrontal cortex of victims of suicide.
Elevated cytokine expression in the orbitofrontal cortex of victims of suicide.
复制标题
自杀受害者的眶额皮质细胞因子表达升高。
DOI：
10.1111/j.1600-0447.2007.01128.x
复制
发表时间：
2008
影响因子：
6.7
通讯作者：
Postolache,TT
中科院分区：
文献类型：
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作者：
Tonelli,LH;Stiller,J;Rujescu,D;Giegling,I;Schneider,B;Maurer,K;Schnabel,A;Möller,H-J;Chen,HH;Postolache,TT
目的：基于细胞因子与抑郁症和自杀之间的相关性，以及自杀受害者脑内炎症标志物增加的证据，本研究检测了自杀受害者眶额皮质细胞因子的表达。方法：在Brodman 11区自杀者（n= 34）和对照组（n= 17）的死后样本中，采用真实的时间RT‐PCR比较肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-1 β、4、5、6和13的mRNA表达。在女性自杀者中发现IL-4的表达增加，在男性自杀者中发现IL-13的表达增加。升高，但不显着的细胞因子的表达也观察到TNF-α在女性suicide victims.Conclusion：据我们所知，这些结果提供了第一个证据的存在2型辅助性T细胞因子的mRNA转录在人类眶额皮质和他们的表达增加在自杀者的大脑。
Objective:Based on the reported association between cytokines with depression and suicide, and evidence of increased markers of inflammation in the brain of suicide victims, the present study examined the expression of cytokines in the orbitofrontal cortex of suicide victims.Method:In a postmortem sample obtained from the Brodman area 11 of suicides (n= 34) and controls (n= 17), real‐time RT‐PCR was used to compare the expression of mRNA species for tumor necrosis factor‐α (TNF‐α), interleukin (IL)‐1β, 4, 5, 6, and 13.Results:Increased expression of IL‐4 was found in women suicide victims and IL‐13 in men suicide victims. Elevated but not significant cytokine expression was also observed for TNF‐α in women suicide victims.Conclusion:To our knowledge, these results provide the first evidence of the presence of mRNA transcripts of type 2 T‐helper cytokines in the human orbitofrontal cortex and their increased expression in the brain of suicides.