Offspring of women exposed in utero to diethylstilbestrol (DES): a preliminary report of benign and malignant pathology in the third generation.
Offspring of women exposed in utero to diethylstilbestrol (DES): a preliminary report of benign and malignant pathology in the third generation.
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子宫内暴露于己烯雌酚 (DES) 的妇女后代：第三代良性和恶性病理的初步报告。
DOI：
10.1097/ede.0b013e318163152a
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Hoover,RobertN
中科院分区：
文献类型：
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作者：
Titus-Ernstoff,Linda;Troisi,Rebecca;Hatch,ElizabethE;Hyer,Marianne;Wise,LaurenA;Palmer,JulieR;Kaufman,Raymond;Adam,Ervin;Noller,Kenneth;Herbst,ArthurL;Strohsnitter,William;Cole,BernardF;Hartge,Patricia;Hoover,RobertN
背景：动物研究表明，产前接触合成雌激素己烯雌酚 (DES) 会导致表观遗传变化，并可能遗传给下一代。具体来说，这些研究表明，产前暴露于 DES 的小鼠的雌性后代中生殖肿瘤的发病率升高。 方法：我们评估了产前暴露于 DES（或缺乏暴露）并经病历证实的女性的后代中发生的癌症和良性病理学诊断。我们的数据来自两个来源：母亲对 8216 名儿子和女儿发生癌症的报告，以及由 793 名女儿组成的子集自我报告的病理学确诊的癌症和良性诊断。结果：尽管统计能力有限，但我们的数据与子宫内暴露于 DES 的妇女的儿子或女儿的癌症总体上没有增加是一致的。根据女儿们报告的病理学确诊，我们发现 DES 与良性乳腺疾病或生殖道疾病的风险之间没有关联。基于3个病例，产前暴露于DES的妇女的女儿的卵巢癌发病率高于预期。结论：我们的数据并不支持产前暴露于DES的妇女的儿子或女儿的癌症风险总体增加，但卵巢癌病例数高于预期。虽然是初步的，但这一发现支持对这些女儿的持续监测。
Background:Animal studies suggest that prenatal exposure to the synthetic estrogen diethylstilbestrol (DES) causes epigenetic changes that may be transmitted to the next generation. Specifically, these studies show an elevated incidence of reproductive tumors in the female offspring of prenatally-exposed mice.Methods:We assessed cancer and benign pathology diagnoses occurring in the offspring of women whose prenatal exposure to DES (or lack of exposure) was verified by medical record. Our data arose from 2 sources: the mothers' reports of cancers occurring in 8216 sons and daughters, and pathology-confirmed cancers and benign diagnoses self-reported by a subset of 793 daughters.Results:Although statistical power is limited, our data are consistent with no overall increase of cancer in the sons or daughters of women exposed in utero to DES. Based on pathology-confirmed diagnoses reported by the daughters, we saw no association between DES and risk of benign breast disease or reproductive tract conditions. Based on 3 cases, the incidence of ovarian cancer was higher than expected in the daughters of women exposed prenatally to DES.Conclusions:Our data do not support an overall increase of cancer risk in the sons or daughters of women exposed prenatally to DES, but the number of ovarian cancer cases was greater than expected. While preliminary, this finding supports continued monitoring of these daughters.