The transcriptional regulatory repertoire of Corynebacterium glutamicum: Reconstruction of the network controlling pathways involved in lysine and glutamate production
The transcriptional regulatory repertoire of Corynebacterium glutamicum: Reconstruction of the network controlling pathways involved in lysine and glutamate production
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DOI：
10.1016/j.jbiotec.2009.12.004
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发表时间：
2010-09-01
影响因子：
4.1
通讯作者：
Tauch, Andreas
中科院分区：
文献类型：
--
作者：
Brinkrolf, Karina;Schroeder, Jasmin;Tauch, Andreas
谷氨酸棒杆菌是革兰氏阳性菌的高G+C分支中研究得最好的生物体之一，也是棒杆菌亚目的新兴模式系统。为了深入了解C.近年来，许多科学团体对谷氨酸的转录调控谱的组分进行了深入研究。本文就C.的转录调控网络的重建方面的全基因组检测的转录调控，共调控相互作用和层次交叉调节的现状。此外，我们提供了这些监管机构和他们的转录调控控制基因参与的碳源葡萄糖，果糖和蔗糖转化为工业相关产品L-赖氨酸和L-谷氨酸的概述。这些数据将有助于我们从系统生物学的角度了解谷氨酸棒杆菌产生L-赖氨酸和L-谷氨酸，并可能为各自生物技术重要代谢途径的计算建模提供基础。(C)2009 Elsevier B. V.保留所有权利。
Corynebacterium glutamicum is one of the best studied organisms of the high G+C branch of Gram-positive bacteria and an emerging model system for the suborder Corynebacterineae. To gain insights into the regulatory gene composition and architecture of the transcriptional regulatory network of C. glutamicum, components of the transcriptional regulatory repertoire were intensively studied by many scientific groups in recent years. In this mini-review, we summarize the present knowledge about the deduced transcriptional regulatory repertoire of C. glutamicum and the current status of transcriptional regulatory network reconstruction with regard to the genome-wide detection of transcriptional regulations, coregulatory interactions and hierarchical cross-regulations. Moreover, we provide an overview of those regulators and their transcriptional regulations controlling genes involved in the conversion of the carbon sources glucose, fructose and sucrose into the industrially relevant products L-lysine and L-glutamate. This data will contribute to our understanding of L-lysine and L-glutamate production by C glutamicum from the perspective of systems biology and may provide the basis for computational modeling of the respective biotechnologically important metabolic pathways. (C) 2009 Elsevier B.V. All rights reserved.