Lysine Acetylation/Deacetylation Modification of Immune-Related Molecules in Cancer Immunotherapy.
Lysine Acetylation/Deacetylation Modification of Immune-Related Molecules in Cancer Immunotherapy.
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癌症免疫治疗中免疫相关分子的赖氨酸乙酰化/脱乙酰化修饰
DOI：
10.3389/fimmu.2022.865975
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
乙酰化和去乙酰化作为主要的翻译后修饰（PTM），是信号传递和细胞代谢的重要因素，并通过组蛋白乙酰转移酶（HAT）和组蛋白去乙酰化酶（HDAC）这两类关键酶的动态过程进行调节。在以前的研究中，赖氨酸乙酰化和去乙酰化的失调已被报道与恶性肿瘤的发生和发展有关。科学家们最近探索了乙酰化/脱乙酰化模式和前瞻性癌症治疗技术，FDA已经批准了四种HDAC抑制剂（HDACi）用于临床治疗。本文综述了赖氨酸乙酰化/去乙酰化修饰在肿瘤免疫治疗中的应用。首先，简要说明乙酰化/脱乙酰化过程和参与其中的相关必需酶。随后，除了与癌症免疫治疗中赖氨酸乙酰化/脱乙酰化修饰相关的几种治疗策略外，还在癌症的背景下列出了参与赖氨酸乙酰化/脱乙酰化过程的多种特异性免疫相关分子。最后，一些与癌症免疫治疗概念相关的前瞻性研究领域提供了详细的分析。本文的综述可为相关领域的研究者提供参考，以期对肿瘤免疫治疗的进一步研究、潜在靶点的选择和有效措施的制定具有指导意义。
As major post-translational modifications (PTMs), acetylation and deacetylation are significant factors in signal transmission and cellular metabolism, and are modulated by a dynamic process via two pivotal categories of enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs). In previous studies, dysregulation of lysine acetylation and deacetylation has been reported to be associated with the genesis and development of malignancy. Scientists have recently explored acetylation/deacetylation patterns and prospective cancer therapy techniques, and the FDA has approved four HDAC inhibitors (HDACi) to be used in clinical treatment. In the present review, the most recent developments in the area of lysine acetylation/deacetylation alteration in cancer immunotherapy were investigated. Firstly, a brief explanation of the acetylation/deacetylation process and relevant indispensable enzymes that participate therein is provided. Subsequently, a multitude of specific immune-related molecules involved in the lysine acetylation/deacetylation process are listed in the context of cancer, in addition to several therapeutic strategies associated with lysine acetylation/deacetylation modification in cancer immunotherapy. Finally, a number of prospective research fields related to cancer immunotherapy concepts are offered with detailed analysis. Overall, the present review may provide a reference for researchers in the relevant field of study, with the aim of being instructive and meaningful to further research as well as the selection of potential targets and effective measures for future cancer immunotherapy strategies.
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影响因子：
56.9
作者：
Choudhary, Chunaram;Kumar, Chanchal;Mann, Matthias
通讯作者：
Mann, Matthias
DOI：
10.4049/jimmunol.1800885
发表时间：
2018-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Badamchi-Zadeh A;Moynihan KD;Larocca RA;Aid M;Provine NM;Iampietro MJ;Kinnear E;Penaloza-MacMaster P;Abbink P;Blass E;Tregoning JS;Irvine DJ;Barouch DH
通讯作者：
Barouch DH
影响因子：
3.3
作者：
Carboni, S;Aboul-Enein, F;Peña-Rossi, C
通讯作者：
Peña-Rossi, C
影响因子：
3.9
作者：
Cacan, Ercan
通讯作者：
Cacan, Ercan
影响因子：
7.3
作者：
Castro F;Cardoso AP;Gonçalves RM;Serre K;Oliveira MJ
通讯作者：
Oliveira MJ