Prolonged Administration Enhances the Renoprotective Effect of Pentoxifylline via Anti-Inflammatory Activity in Streptozotocin-Induced Diabetic Nephropathy
Prolonged Administration Enhances the Renoprotective Effect of Pentoxifylline via Anti-Inflammatory Activity in Streptozotocin-Induced Diabetic Nephropathy
复制标题
长期给药可通过链脲佐菌素诱导的糖尿病肾病的抗炎活性增强己酮可可碱的肾脏保护作用
作者：
K. Han;S. Han;Han;Y. Kang;D. Cha
己酮茶碱（PTX）在糖尿病肾病中具有抗炎和肾保护作用，其有益作用尚不完全清楚。本研究探讨长期给药PTX （40mg /kg，每次口服）是否对链脲佐菌素引起的糖尿病肾病有效。糖尿病大鼠尿蛋白含量高于对照组大鼠。PTX治疗4周后数量保持不变，8周后减少。单核细胞趋化肽-1 （MCP-1）和小鼠单克隆抗单核细胞/巨噬细胞抗体（ED-1）阳性细胞的积累在未治疗的糖尿病大鼠中高于对照组。4周时，PTX可改善尿MCP-1排泄和ED-1阳性细胞间质浸润。此外，在糖尿病大鼠中，PTX给药4周可抑制肾脏炎症反应，给药8周可预防蛋白尿。这些发现支持了延长给药时间增强PTX保护作用的假设。
The beneficial effects of pentoxifylline (PTX), which has an anti-inflammatory and renoprotective effect in diabetic nephropathy, are not completely understood. This study investigates whether prolonged administration of PTX (40 mg/kg, per oral) is effective in streptozotocin-induced diabetic nephropathy. The amount of urinary protein was higher in the diabetic rats than in the control rats. The amount remained unchanged after 4 weeks and decreased after 8 weeks of PTX treatment. Accumulation of monocyte chemoattractant peptide-1 (MCP-1) and mouse monoclonal anti-monocyte/macrophage antibody (ED-1) positive cells was higher in untreated diabetic rats than in the control rats. PTX administration ameliorated the urinary MCP-1 excretion and interstitial infiltration of ED-1 positive cells at 4 weeks. Further, in diabetic rats, administration of PTX for 4 weeks inhibited the renal inflammatory reaction, and when administration for 8 weeks, it prevented proteinuria. These findings support the hypothesis that prolonged administration enhances the protective effects of PTX.
影响因子：
19.6
作者：
Festa, A;D'Agostino, R;Haffner, SM
通讯作者：
Haffner, SM
胰岛素和糖尿病。
DOI：
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发表时间：
1986
期刊：
Transactions of the Association of American Physicians
影响因子：
--
作者：
Mako,ME;Rubenstein,AH
通讯作者：
Rubenstein,AH
影响因子：
158.5
作者：
LEWIS, EJ;HUNSICKER, LG;ROHDE, RD
通讯作者：
ROHDE, RD