Analytical theory for extracellular electrical stimulation of nerve with focal electrodes. I. Passive unmyelinated axon.
Analytical theory for extracellular electrical stimulation of nerve with focal electrodes. I. Passive unmyelinated axon.
复制标题
用焦点电极对神经进行细胞外电刺激的分析理论。
DOI：
10.1016/s0006-3495(88)83035-2
复制
发表时间：
1988
影响因子：
3.4
通讯作者：
Spelman,FA
中科院分区：
文献类型：
--
作者：
Rubinstein,JT;Spelman,FA
推导了应用细胞外场中无源无髓鞘纤维的电缆模型。该解对于任意时变的应用场是有效的，可以通过分析或数值方式确定该场。给出了简单的分析计算。他们解释了多种已知现象，并预测了细胞外电刺激的一些先前未描述的特性。施加场中光纤的偏振行为类似于刺激的空间高通和时间低通滤波器的输出。高频刺激导致纤维激励的空间范围更加受限，相对于低频刺激产生的电流扩散有效地减少了电流扩散。细胞外测量的 Chronaxie 是电极相对于受刺激纤维的位置的函数，并且其值可能与细胞内获得的值有很大不同。通过电刺激猕猴耳蜗获得的心理物理阈值的频率依赖性与单纤维被动响应的频率依赖性密切相关。
The cable model of a passive, unmyelinated fiber in an applied extracellular field is derived. The solution is valid for an arbitrary, time-varying, applied field, which may be determined analytically or numerically. Simple analytical computations are presented. They explain a variety of known phenomena and predict some previously undescribed properties of extracellular electrical stimulation. The polarization of a fiber in an applied field behaves like the output of a spatial high-pass and temporal low-pass filter of the stimulus. High-frequency stimulation results in a more spatially restricted region of fiber excitation, effectively reducing current spread relative to that produced by low-frequency stimulation. Chronaxie measured extracellularly is a function of electrode position relative to the stimulated fiber, and its value may differ substantially from that obtained intracellularly. Frequency dependence of psychophysical threshold obtained by electrical stimulation of the macaque cochlea closely follows the frequency dependence of single-fiber passive response.