The Efficacy of Sodium Citrate in the Treatment of Severe Alkali Burns of the Eye Is Influenced by the Route of Administration
The Efficacy of Sodium Citrate in the Treatment of Severe Alkali Burns of the Eye Is Influenced by the Route of Administration
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柠檬酸钠治疗眼睛严重碱烧伤的疗效受给药途径的影响
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
C. Paterson
中科院分区：
文献类型：
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作者：
R. Pfister;J. L. Haddox;C. Paterson
用10%柠檬酸钠局部或皮下注射处理12 mm、1 N NaOH碱烧伤35秒的兔角膜。在局部治疗组中，18.8%的柠檬酸盐治疗角膜溃疡，而对照组为78.6%（0.01 > p > 0.001）。柠檬酸盐治疗组中出现的溃疡不仅在统计学上更少，而且严重程度也显着降低。64.3%的对照眼出现带状角膜病变，但柠檬酸盐治疗眼无带状角膜病变。皮下注射柠檬酸盐可将溃疡发生率从对照组的75%降至给药组的43%。虽然这可能代表一种趋势，但不具有统计学显著性（p = 0.073）。合并胃肠外给药组中的后弹力层膨出和穿孔，对照组的发生率为56%，柠檬酸盐给药组为14%。该显著差异（p = 0.017）清楚地表明，皮下给药动物的对照组溃疡严重程度更高。这些结果表明，柠檬酸钠在局部应用时对预防碱烧伤后的角膜溃疡和穿孔具有最有利的效果。
Rabbit corneas subjected to 12 mm, 1 N NaOH alkali burns for 35 seconds were treated with 10% sodium citrate topically or by subcutaneous injections. In the topically treated group, 18.8% of the citrate-treated corneas ulcerated compared to 78.6% of the controls (0.01 > p > 0.001). The ulcers developing in the citrate-treated group were not only statistically fewer but were significantly less severe in degree. Band keratopathy developed in 64.3% of the control eyes but in none of the citrate-treated eyes. Subcutaneous citrate reduced the incidence of ulceration from 75% in the control to 43% in the treated animals. Although this may represent a trend, it is not statistically significant (p = 0.073). Combining the descemetoceles and perforations in the parenterally treated groups yields an incidence of 56% in the controls and 14% in the citrate-treated animals. This significant difference (p = 0.017) clearly shows the greater severity of ulceration in the control group of the subcutaneously treated animals. These results show that sodium citrate has a most favorable effect in the prevention of corneal ulceration and perforation after alkali burns when applied topically.