Functional testing in animal models of spinal cord injury: not as straight forward as one would think.
Functional testing in animal models of spinal cord injury: not as straight forward as one would think.
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DOI：
10.3389/fnint.2013.00085
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发表时间：
2013-11-26
影响因子：
3.5
通讯作者：
Magnuson DS
中科院分区：
文献类型：
--
作者：
Fouad K;Hurd C;Magnuson DS
在探索脊髓损伤 (SCI) 的潜在治疗方法时，就转化考虑而言，功能恢复被认为是最相关的结果指标。然而，评估这种恢复和潜在的治疗效果具有挑战性，而且其中的陷阱常常被低估。其后果是，在许多情况下，积极的结果无法可靠地复制，并且看似缺乏效果的可能治疗方法已被过早地驳回。在本文中，我们回顾了病变位置/严重程度与功能结果之间的关系，并特别考虑了地板和天花板效应。讨论了补偿策略的作用、将其与真正恢复区分开来的挑战，以及考虑到动物测试固有的可变性，将功能与受伤前水平进行比较。最终，我们提出了一系列考虑因素，以增强 SCI 动物模型中功能分析的能力。
When exploring potential treatments for spinal cord injury (SCI), functional recovery is deemed the most relevant outcome measure when it comes to translational considerations. Yet, assessing such recovery and potential treatment effects is challenging and the pitfalls are frequently underestimated. The consequences are that in many cases positive results cannot be reliably replicated, and likely treatments that appear to lack effects have been dismissed prematurely. In this article we review the relationships between lesion location/severity and functional outcomes with specific consideration given to floor and ceiling effects. The roles of compensatory strategies, the challenges of distinguishing them from bona fide recovery, and of comparing function to pre-injury levels given the variability inherent in animal testing are discussed. Ultimately, we offer a series of considerations to enhance the power of functional analysis in animal models of SCI.