Association between personal use of hair dyes and lymphoid neoplasms in Europe
Association between personal use of hair dyes and lymphoid neoplasms in Europe
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DOI：
10.1093/aje/kwj187
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发表时间：
2006-07-01
影响因子：
5
通讯作者：
Brennan, Paul
中科院分区：
文献类型：
--
作者：
de Sanjose, Silvia;Benavente, Yolanda;Brennan, Paul
染发剂已被评估为可能对动物具有诱变性和致癌性。关于人类癌症风险和染发剂使用之间关系的研究得出了不一致的结果。作者评估了与个人使用染发剂相关的淋巴系恶性肿瘤的风险。分析包括来自捷克共和国、法国、德国、爱尔兰、意大利和西班牙的2,302例淋巴肿瘤病例和2,417例以医院或人口为基础的对照(1998-2003年)。据报道，74%的女性和7%的男性使用染发剂。染发剂使用者患淋巴瘤的风险比从不使用染发剂者高19%(优势比OR=1.19，95%可信区间：1.00，1.4 1)；每年染发剂使用12次或以上者患淋巴瘤的风险增加2 6%(OR=1.2 6，95%CI：1.0 0，1.6 0；线性趋势P=0.414)。1980年前开始染发的人群(OR=1.37，95%CI：1.09，1.72)和1980年前只使用染发剂的人群(OR=1.62，95%CI：1.10，2.40)患淋巴瘤的风险较高。个人使用染发剂与患淋巴瘤风险的适度增加有关，特别是在1980年之前使用染发剂的妇女和人群中。与这种风险相关的特定化合物仍有待阐明。
Hair dyes have been evaluated as possibly being mutagenic and carcinogenic in animals. Studies of the association between human cancer risk and use of hair dyes have yielded inconsistent results. The authors evaluated the risk of lymphoid malignancies associated with personal use of hair dyes. The analysis included 2,302 incident cases of lymphoid neoplasms and 2,417 hospital- or population-based controls from the Czech Republic, France, Germany, Ireland, Italy, and Spain (1998-2003). Use of hair dyes was reported by 74% of women and 7% of men. Lymphoma risk among dye users was significantly increased by 19% in comparison with never use (odds ratio (OR) = 1.19, 95% confidence interval (CI): 1.00, 1.41) and by 26% among persons who used hair dyes 12 or more times per year (OR = 1.26, 95% CI: 1.00, 1.60; p for linear trend = 0.414). Lymphoma risk was significantly higher among persons who had started coloring their hair before 1980 (OR = 1.37, 95% CI: 1.09, 1.72) and persons who had used hair dyes only before 1980 (OR = 1.62, 95% CI: 1.10, 2.40). Personal use of hair dyes is associated with a moderate increase in lymphoma risk, particularly among women and persons who used dyes before 1980. Specific compounds associated with this risk remain to be elucidated.