Catechol-O-Methyltransferase Va1158Met polymorphism and clinical characteristics in first episode non-affective psychosis
Catechol-O-Methyltransferase Va1158Met polymorphism and clinical characteristics in first episode non-affective psychosis
复制标题
DOI：
10.1002/ajmg.b.30639
复制
发表时间：
2008-07-05
影响因子：
2.8
通讯作者：
Vazquez-Barquero, Jose Luis
中科院分区：
文献类型：
--
作者：
Pelayo-Teran, Jose Maria;Crespo-Facorro, Benedicto;Vazquez-Barquero, Jose Luis
儿茶酚-O-甲基转移酶 (COMT) Va1158Met 多态性已被确定为精神分裂症的潜在病因。有人提出这种多态性可能与特定的临床标志物相关。本研究的目的是评估 COMT Val158Met 多态性基因型对首发精神病发作时表型表达的影响。研究人员对 169 名首次发作非情感性精神病的白人初治患者进行了发病年龄、DUP、SANS 和 SAPS（积极维度、紊乱维度和消极维度）的研究。使用相关区域的 PCR 扩增，然后用 NlaIII 消化和电泳来对 COMT Val158Met 多态性进行分型。以 COMT 和性别作为自变量进行多变量 ANCOVA。与 Met 携带者相比，Val/Val 基因型患者的 SANS 负向维度评分水平显着较高（F：3.539；P = 0.031），并且发病年龄更年轻（F：4.649；P = 0.011）。我们的研究结果表明，Val 等位基因与疾病预后不良相关的发病表型特征相关。这些数据表明 COMT 基因型可能在精神分裂症和其他精神障碍的病因模型中发挥作用。 (C) 2007 Wiley-Liss, Inc.
Catechol-O-methyltransferase (COMT) Va1158Met polymorphism has been identified as a potential etiologic factor in schizophrenia. It has been proposed that this polymorphism could be associated with specific clinical markers. The aim of the study was to evaluate the influence of COMT Val158Met polymorphism genotype in the phenotypic expression of first episode psychosis at onset. Age of onset, DUP, SANS, and SAPS (positive, disorganized, and negative dimensions) were studied in 169 Caucasian drug-naive patients with a first-episode of non-affective psychosis. The COMT Val158Met polymorphism was typed using PCR amplification of the relevant region followed by digestion with NlaIII and electrophoresis. A multivariate ANCOVA was performed with COMT and gender as independent variables. Patients with Val/Val genotype had significantly higher levels of SANS negative dimension scores (F: 3.539; P = 0.031) and had a younger age of onset (F: 4.649; P = 0.011) than Met carriers. Our findings suggest that the Val allele is associated with onset phenotypic features related to a poor prognosis of the illness. These data would indicate that COMT genotype may have a role in the etiological model for schizophrenia and other psychotic disorders. (C) 2007 Wiley-Liss, Inc.