Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease.
Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease.
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DOI：
10.2217/fmb.13.168
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发表时间：
2014
影响因子：
3.1
通讯作者：
McClane BA
中科院分区：
文献类型：
--
作者：
Uzal FA;Freedman JC;Shrestha A;Theoret JR;Garcia J;Awad MM;Adams V;Moore RJ;Rood JI;McClane BA
产气荚膜梭菌使用其>16种毒素的武库在人类和动物中引起组织毒性和肠道感染。目前还不清楚为什么这种细菌会产生如此多不同的毒素，特别是因为许多毒素针对宿主细胞的质膜。然而，现在已经确定C.产气荚膜梭菌在组织毒性感染期间使用染色体编码的α毒素（磷脂酶C）和产气荚膜梭菌溶素O（成孔毒素）。相反，这种细菌通过使用由移动的遗传元件编码的毒素引起肠道疾病，包括C。产气荚膜杆菌肠毒素、坏死性肠炎毒素B样、肉毒杆菌毒素和β毒素。与产气荚膜梭菌溶素O一样，在肠道疾病中具有既定作用的毒素形成膜孔。然而，肠道疾病相关毒素在其产生时（孢子形成与营养生长）的靶特异性以及对肠道蛋白酶的敏感性方面有所不同。产生许多具有不同特征的毒素可能赋予C.所以它能引起一系列疾病
Clostridium perfringens uses its arsenal of >16 toxins to cause histotoxic and intestinal infections in humans and animals. It has been unclear why this bacterium produces so many different toxins, especially since many target the plasma membrane of host cells. However, it is now established that C. perfringens uses chromosomally encoded alpha toxin (a phospholipase C) and perfringolysin O (a pore-forming toxin) during histotoxic infections. In contrast, this bacterium causes intestinal disease by employing toxins encoded by mobile genetic elements, including C. perfringens enterotoxin, necrotic enteritis toxin B-like, epsilon toxin and beta toxin. Like perfringolysin O, the toxins with established roles in intestinal disease form membrane pores. However, the intestinal disease-associated toxins vary in their target specificity, when they are produced (sporulation vs vegetative growth), and in their sensitivity to intestinal proteases. Producing many toxins with diverse characteristics likely imparts virulence flexibility to C. perfringens so it can cause an array of diseases.
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影响因子：
3.1
作者：
Cheung, Jackie K.;Keyburn, Anthony L.;Rood, Julian I.
通讯作者：
Rood, Julian I.
影响因子：
3.8
作者：
Awad, MM;Ellemor, DM;Rood, JI
通讯作者：
Rood, JI
影响因子：
3.7
作者：
Autheman D;Wyder M;Popoff M;D'Herde K;Christen S;Posthaus H
通讯作者：
Posthaus H
影响因子：
6.4
作者：
Bannam TL;Yan XX;Harrison PF;Seemann T;Keyburn AL;Stubenrauch C;Weeramantri LH;Cheung JK;McClane BA;Boyce JD;Moore RJ;Rood JI
通讯作者：
Rood JI
影响因子：
5.6
作者：
Briggs DC;Naylor CE;Smedley JG 3rd;Lukoyanova N;Robertson S;Moss DS;McClane BA;Basak AK
通讯作者：
Basak AK