EFFECTS OF CHANGES IN PACO2 ON CEREBRAL BLOOD VOLUME, BLOOD FLOW, AND VASCULAR MEAN TRANSIT TIME
EFFECTS OF CHANGES IN PACO2 ON CEREBRAL BLOOD VOLUME, BLOOD FLOW, AND VASCULAR MEAN TRANSIT TIME
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DOI：
10.1161/01.str.5.5.630
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发表时间：
1974-01-01
期刊：
影响因子：
8.3
通讯作者：
TERPOGOS.MM
中科院分区：
文献类型：
--
作者：
GRUBB, RL;RAICHLE, ME;TERPOGOS.MM
通过连续测定血管示踪剂15 O-标记碳氧血红蛋白的平均通过时间和可扩散示踪剂15 O-标记水的平均通过时间，研究了猕猴在15 ~ 76 mmHg PaCO 2急性变化时脑血容量（CBV）、脑血流量（CBF）和脑血管平均通过时间（tv）之间的关系。在此范围内，CBV = 0.041PaCO_2 + 2.0呈显著的线性关系，PaCO_2每变化一次，CBV的变化为0.041ml/100 g灌注组织。当PaCO_2正常时（37 ℃），平均值为3.5 ml/100 g，CBV与CBF呈非线性关系，其关系式为CBV = 0.80 CBF ~（0.38）。CBF与PaCO 2之间存在显著的线性关系。这可以用公式CBF = 1.8 PaCO 2 - 16.75来描述。对于PaCO 2的每一个变化，CBF的变化为1.8 ml/100 gm/min。当PaCO_2正常值（37 ℃）时，CBF平均值为50 ml/100 g/min，CBV与tv呈非线性关系，可用公式tC_（15）O = 41 CBF-0.62表示。
The relationships between cerebral blood volume (CBV), cerebral blood flow (CBF), and the cerebral vascular mean transit time (tv) during acute changes in the PaCO2over a range of 15 to 76 torr were investigated in vivo in rhesus monkeys by serially determining the mean transit time of a vascular tracer,15O-labeled carboxyhemoglobin, and the mean transit time of a diffusible tracer,15O-labeled water. Over this range of PaCO2, a significant linear relationship of CBV = 0.041 PaCO2+ 2.0 was found. For each one torr change in PaCO2, there is a change in CBV of 0.041 ml/100 gm of perfused tissue. At a normocarbic value of PaCO2(37 torr), an average value of 3.5 ml/100 gm was found. A nonlinear relationship of CBV and CBF was found. This relationship is expressed in the equation, CBV = 0.80 CBF0.38. A significant linear relationship was found between CBF and PaCO2. This was described by the equation, CBF = 1.8 PaCO2- 16.75. For each one torr change in the PaCO2, there is a 1.8 ml/100 gm per minute change in the CBF. At a normocarbic value of PaCO2(37 torr), an average value of CBF of 50 ml/100 gm per minute was found. The relationship of CBV and tvwas nonlinear and was expressed in the equation, tC15O= 41 CBF-0.62.