Transition-metal-catalyzed C-N cross-coupling reactions of N-unsubstituted sulfoximines: a review
Transition-metal-catalyzed C-N cross-coupling reactions of N-unsubstituted sulfoximines: a review
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DOI：
10.1080/17415993.2018.1471142
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发表时间：
2018-11-02
影响因子：
2.2
通讯作者：
Nikpassand, Mohammad
中科院分区：
文献类型：
--
作者：
Hosseinian, Akram;Fekri, Leila Zare;Nikpassand, Mohammad
近年来，N-官能化亚砜亚胺类化合物由于其广泛的生物活性而引起了药物化学家的极大关注。这类有机硫化合物在农业化学中也有许多应用。除了这些优点，亚砜亚胺是不对称合成中最重要和最通用的手性助剂和配体之一。作为这些的结果，许多努力已经致力于开发有效的策略，以合成N-官能化的亚砜亚胺。一个有效的，实用的，和多功能的标题化合物的合成策略涉及过渡金属催化的交叉偶联反应的容易获得的NH-亚砜亚胺与各种亲电合作伙伴。在这篇综述中，我们强调了一些最近的发现和进展，在这个有趣的和重要的研究竞技场。首先讨论了N-烷基化反应。随后是金属催化的N-烯基化和N-炔基化反应。最后，N-芳基化反应将涵盖在审查结束。[图形]。
In recent years, N-functionalized sulfoximines have attracted the significant attention of medicinal chemists due to their wide spectrum of biological activities. This class of organosulfur compounds has also found a number of applications in agricultural chemistry. In addition to these benefits, sulfoximines are one of the most important and versatile chiral auxiliaries and ligands in asymmetric syntheses. As a result of these, numerous efforts have been devoted to the development of effective strategies towards the synthesis of N-functionalized sulfoximines. An efficient, practical, and versatile strategy for the synthesis of titled compounds involves the transition-metal-catalyzed cross-coupling reactions of easily accessible NH-sulfoximines with various electrophilic partners. In this review, we highlight a number of recent discoveries and advances in this interesting and important research arena. The N-alkylation reactions are discussed first. This is followed by metal-catalyzed N-alkenylation and N-alkynylation reactions. Finally, N-arylation reactions will be covered at the end of the review.[GRAPHICS].