Pituitary somatotroph adenoma producing growth hormone (GH)-releasing hormone (GHRH) with an elevated plasma GHRH concentration: a model case for autocrine and paracrine regulation of GH secretion by GHRH.
Pituitary somatotroph adenoma producing growth hormone (GH)-releasing hormone (GHRH) with an elevated plasma GHRH concentration: a model case for autocrine and paracrine regulation of GH secretion by GHRH.
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垂体生长激素腺瘤产生生长激素（GH）释放激素（GHRH），且血浆 GHRH 浓度升高：GHRH 自分泌和旁分泌调节 GH 分泌的模型。
DOI：
10.1210/jcem.84.9.6008
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
T. Nagashima
中科院分区：
文献类型：
--
作者：
A. Matsuno;H. Katakami;N. Sanno;Y. Ogino;R. Osamura;S. Matsukura;N. Shimizu;T. Nagashima
本文报告一例肢端肥大症患者，伴有垂体生长激素腺瘤并伴有血浆GHRH浓度极高。腺瘤切除成功后，术前血浆GHRH浓度恢复到正常水平。免疫组织化学和原位杂交证实腺瘤中GHRH的产生和GHRH基因的表达。原位杂交检测GHRH受体信使核糖核酸的表达。GH和GHRH免疫组织化学双重染色显示GH和GHRH共存于单个腺瘤细胞。这些发现证实了内源性GHRH对腺瘤细胞产生GH的自分泌或旁分泌调节。最近已证实在脑下垂体合成GHRH，然而，以前还没有关于产生GHRH的垂体生长激素腺瘤与血浆GHRH浓度升高相关的报道。这种产生GHRH的腺瘤的存在表明局部产生的GHRH可能在生长激素腺瘤的进展中起作用，即单克隆性建立的生长激素腺瘤在局部产生的GHRH的影响下进一步发展。证明生长激素腺瘤产生GHRH对于阐明生长激素产生的自分泌或旁分泌调节以及人生长激素腺瘤的进展具有重要意义。
An acromegalic patient with a pituitary somatotroph adenoma associated with an extremely elevated plasma GHRH concentration is presented. The preoperatively high concentration of plasma GHRH returned to the normal level after successful removal of the adenoma. GHRH production and GHRH gene expression were confirmed in the adenoma by studies including immunohistochemistry and in situ hybridization. Expression of GHRH receptor messenger ribonucleic acid was verified by in situ hybridization. Immunohistochemical double staining for GH and GHRH revealed their colocalization in single adenoma cells. These findings confirmed the autocrine or paracrine regulation of GH production by endogenous GHRH from the adenoma cells. GHRH synthesis in the pituitary gland has recently been demonstrated, however, there have been no previous reports of a GHRH-producing pituitary somatotroph adenoma associated with an elevated plasma GHRH concentration. The existence of this GHRH-producing adenoma suggests a possible role of locally generated GHRH in the progression of somatotroph adenomas, i.e. the monoclonally established somatotroph adenomas develop further under the influence of locally produced GHRH. The demonstration of GHRH production by this somatotroph adenoma is of importance in clarifying the autocrine or paracrine regulation of GH production and the progression of human somatotroph adenomas.
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DOI：
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DOI：
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