Serum levels of soluble CD163 in patients with systemic sclerosis
Serum levels of soluble CD163 in patients with systemic sclerosis
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DOI：
10.1007/s00296-010-1691-z
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发表时间：
2012-02-01
影响因子：
4
通讯作者：
Ihn, Hironobu
中科院分区：
文献类型：
--
作者：
Nakayama, Wakana;Jinnin, Masatoshi;Ihn, Hironobu
巨噬细胞可能在系统性硬化症（SSc）的发病机制中发挥作用，CD163阳性M2巨噬细胞是纤维化诱导细胞因子的潜在重要来源。然而，M2巨噬细胞和SSc之间的联系尚未建立。目的是评估可溶性CD 163（sCD 163）血清水平可能是SSc的有用标志物，反映了这种疾病中巨噬细胞的M2活化。采用特异性酶联免疫吸附法检测43例硬皮病患者、10例硬皮病谱系障碍（SSD）患者和12例健康对照者血清sCD 163水平。SSc患者血清sCD 163水平显著高于健康对照组。SSD患者sCD 163水平高于健康对照组，低于SSc患者。血清sCD 163水平升高的SSc患者的右心室收缩压显著升高，% DLco水平显著降低，病程显著缩短。这些结果表明，sCD 163水平可能会增加成比例的疾病的进展，表明CD 163参与的发病机制SSc。血清sCD 163水平可能是SSc患者早期肺动脉高压的一个指标。
Macrophages may play a role in the pathogenesis of systemic sclerosis (SSc), and CD163-positive M2 macrophages are potentially important source for fibrosis-inducing cytokines. However, no link between M2 macrophages and SSc has been established. The aim is to evaluate the possibility that serum levels of soluble CD163 (sCD163) can be a useful marker for SSc, reflecting M2 activation of macrophages in this disease. Serum sCD163 levels of 43 patients with SSc, 10 patients with scleroderma spectrum disorder (SSD), and 12 healthy controls were measured with specific enzyme-linked immunosorbent assays. SSc patients had significantly higher serum sCD163 levels than healthy controls. The sCD163 levels in SSD patients were higher than healthy controls and lower than SSc patients. Significantly higher right ventricular systolic pressure and lower % DLco levels, and shorter duration of disease were seen in SSc patients with elevated serum sCD163 levels than those with normal levels. These results suggest that sCD163 levels may be increased in proportion to the progression of this disease, indicating the involvement of CD163 in the pathogenesis of SSc. Furthermore, serum sCD163 levels may be a marker of pulmonary hypertension at the early stage in patients with SSc.