Treatment of experimental chronic pulmonary mycoplasmosis
Treatment of experimental chronic pulmonary mycoplasmosis
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DOI：
10.1016/j.ijantimicag.2006.04.008
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发表时间：
2006-09-01
影响因子：
10.8
通讯作者：
Hardy, R. Doug
中科院分区：
文献类型：
--
作者：
Fonseca-Aten, Monica;Rios, Ana Maria;Hardy, R. Doug
肺炎支原体感染与慢性肺部疾病有关。慢性肺支原体病的治疗尚未得到很好的研究。BALB/c小鼠鼻内接种M. pneumoniae或无菌培养基（未感染的对照）。在疾病的慢性期（接种后18个月），每天用泰利霉素或安慰剂治疗感染的小鼠10天。在治疗前和泰利霉素完成后1天评价小鼠（n = 43）。与给予安慰剂的感染小鼠相比，在感染后18个月用泰利霉素治疗感染小鼠显著降低了慢性肺组织学炎症;然而，这种治疗没有改善气道阻塞或气道高反应性。可能需要超过10天的治疗来改善肺功能。(c)2006年Elsevier B. V.和国际化疗学会。All rights reserved.
Mycoplasma pneumoniae infection has been associated with chronic lung disease. Treatment of chronic pulmonary mycoplasmosis has not been well investigated. BALB/c mice were intranasally inoculated once with M. pneumoniae or with sterile media (uninfected controls). Infected mice were treated with telithromycin or placebo daily for 10 days in the chronic phase of disease (18 months after inoculation). Mice (n = 43) were evaluated before therapy and I day after completion of telithromycin. Treatment of infected mice with telithromycin at 18 months after infection significantly reduced chronic pulmonary histological inflammation compared with infected mice given placebo; however, this treatment did not improve airway obstruction or airway hyperresponsiveness. Therapy longer than 10 days may be necessary to improve pulmonary function. (c) 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.