Elastomeric nanocomposite scaffolds made from poly (glycerol sebacate) chemically crosslinked with carbon nanotubes.
Elastomeric nanocomposite scaffolds made from poly (glycerol sebacate) chemically crosslinked with carbon nanotubes.
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DOI：
10.1039/c4bm00222a
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发表时间：
2015-01-01
影响因子：
6.6
通讯作者：
Khademhosseini A
中科院分区：
文献类型：
--
作者：
Gaharwar AK;Patel A;Dolatshahi-Pirouz A;Zhang H;Rangarajan K;Iviglia G;Shin SR;Hussain MA;Khademhosseini A
碳纳米管（CNT）基纳米复合材料通常具有诸如高刚度、导电性和热稳定性的性质，并且已经被研究用于各种生物医学和生物技术应用。然而，目前的设计方法利用碳纳米管作为物理填料，因此，真正的潜力，碳纳米管为基础的纳米复合材料尚未实现。在这里，我们介绍了一种通用的方法，制造刚性，弹性体纳米复合材料的聚（癸二酸甘油酯）（PGS）和碳纳米管。纳米管和聚合物链之间的共价交联导致了在传统纳米复合材料中没有观察到的新特性组合。添加1%的碳纳米管导致的拉伸模量增加了5倍，压缩模量增加了6倍，与单独的PGS相比，这是远远上级以前报道的研究CNT为基础的纳米复合材料。尽管机械刚度显著增加，但网络的弹性没有受到损害，并且所得纳米复合材料显示出超过94%的恢复率。这项研究表明，碳纳米管的化学共轭的PGS骨干的结果在刚性和弹性的纳米复合材料。此外，使用人间充质干细胞（hMSC）的体外研究表明，将CNT并入PGS网络显著增强了接种的hMSC的分化潜力，使其潜在地适用于从肌肉骨骼组织工程中的支架到生物医学装置中的生物传感器的应用。
Carbon nanotube (CNT)-based nanocomposites often possess properties such as high stiffness, electrical conductivity, and thermal stability and have been studied for various biomedical and biotechnological applications. However, the current design approaches utilize CNTs as physical filler, and thus, the true potential of CNT-based nanocomposites has not been achieved. Here, we introduce a general approach of fabricating stiff, elastomeric nanocomposites from poly(glycerol sebacate) (PGS) and CNTs. The covalent crosslinking between the nanotubes and polymer chains resulted in novel property combinations that are not observed in conventional nanocomposites. The addition of 1% CNTs resulted a five-fold increase in the tensile modulus and a six-fold increase in compression modulus compared with PGS alone, which is far superior to the previously reported studies for CNT-based nanocomposites. Despite significant increase in mechanical stiffness, the elasticity of the network was not compromised and the resulting nanocomposites showed more than 94% recovery. This study demonstrates that the chemical conjugation of CNTs to a PGS backbone results in stiff and elastomeric nanocomposites. Additionally, in vitro studies using human mesenchymal stem cells (hMSCs) indicated that the incorporation of CNTs to PGS network significantly enhanced the differentiation potential of the seeded hMSCs rendering them potentially suitable for applications ranging from scaffolding in musculoskeletal tissue engineering to biosensors in biomedical devices.