Thymus atrophy and double-positive escape are common features in infectious diseases.
Thymus atrophy and double-positive escape are common features in infectious diseases.
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DOI：
10.1155/2012/574020
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发表时间：
2012
影响因子：
2.2
通讯作者：
Savino W
中科院分区：
文献类型：
--
作者：
de Meis J;Aurélio Farias-de-Oliveira D;Nunes Panzenhagen PH;Maran N;Villa-Verde DM;Morrot A;Savino W
The thymus is a primary lymphoid organ in which bone marrow-derived T-cell precursors undergo differentiation, leading to migration of positively selected thymocytes to the T-cell-dependent areas of secondary lymphoid organs. This organ can undergo atrophy, caused by several endogenous and exogenous factors such as ageing, hormone fluctuations, and infectious agents. This paper will focus on emerging data on the thymic atrophy caused by infectious agents. We present data on the dynamics of thymus lymphocytes during acute Trypanosoma cruzi infection, showing that the resulting thymus atrophy comprises the abnormal release of thymic-derived T cells and may have an impact on host immune response.
