Effect of surface tension on alveolar surface area.
Effect of surface tension on alveolar surface area.
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表面张力对肺泡表面积的影响。
DOI：
10.1152/japplphysiol.00126.2001
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Topulos,GeorgeP
中科院分区：
文献类型：
--
作者：
Butler,JamesP;Brown,RichardE;Stamenovic,Dimitrije;Morris,JohnP;Topulos,GeorgeP
在固定的肺体积（VI）下，表面张力的改变改变肺泡表面积（S）和肺回缩（PI）。Wilson（26）使用来自固定肺的数据（1，9）定量了S与PI的等容变化。我们在新鲜的离体兔肺中重新研究了这个问题，有两个重要的差异。首先，我们通过使用漫射光散射测量S的分数变化，避免固定期间组织和表面力平衡的潜在破坏。第二，我们通过雾化聚二甲基硅氧烷给肺通气来改变表面张力，与灌洗相比，残留液体少得多。我们发现，S在低和中VI（处理表面张力>对照）下降低约Wilson估计值的一半，并且几乎不受高VI下处理的影响。这表明，随着表面张力的增加，1）与未固定的肺相比，血管灌注固定的肺有更大的间隔回缩，2）Pland的增加更大，S的丢失比预期的少。
At fixed lung volume (Vl), alterations in surface tension change alveolar surface area (S) and lung recoil (Pl). Wilson (26), using data from fixed lungs (1, 9), quantified the isovolume change in S with Pl. We reexamined this question in fresh excised rabbit lungs, with two important differences. First, we measured fractional changes in S by using diffuse light scattering, avoiding the potential upset of the balance of tissue and surface forces during fixation. Second, we altered surface tension by ventilating the lungs with nebulized polydimethylsiloxane, with much less residual fluid compared with lavage. We found that S decreased at low and mid Vl(treatment surface tension > control) by about half of Wilson's estimates and was nearly unaffected by treatment at high Vl. This suggests that with increased surface tension there is1) greater septal retraction in lungs fixed by vascular perfusion compared with unfixed lungs and2) a greater increase in Pland less loss of S than would have been predicted.