Development genetic analysis of general cognitive ability from 1 to 12 years in a sample of adoptees, biological siblings, and twins
Development genetic analysis of general cognitive ability from 1 to 12 years in a sample of adoptees, biological siblings, and twins
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DOI：
10.1016/s0160-2896(02)00112-5
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发表时间：
2003-01-01
期刊：
影响因子：
3
通讯作者：
Hewitt, JK
中科院分区：
文献类型：
--
作者：
Bishop, EG;Cherny, SS;Hewitt, JK
我们报告了一项纵向遗传分析，该分析结合了双胞胎以及收养和非收养的兄弟姐妹，以研究从婴儿期到青春期过渡的一般认知能力病因学的连续性和变化。儿童时期的研究表明，遗传力增加，共享环境影响减少，遗传因素有助于变化和连续性，共享环境完全有助于连续性，非共享环境完全有助于变化。来自纵向双胞胎研究的双胞胎（LTS；1 年时 224 对同卵双胞胎，189 对同性 DZ 对）以及来自科罗拉多收养项目的收养（遗传无关）和非收养（生物学）兄弟姐妹（CAP；1 年时分别为 107 对和 87 对）在 2、3、4、7、9 和 10 岁时再次进行评估，非双胞胎兄弟姐妹也接受了评估。评估时为12年。纵向模型拟合支持了上述源自儿童研究的假设，但有两个例外。非共享的环境影响有助于童年中期的连续性和变化。最引人注目的例外是，在向青春期过渡期间，遗传因素不再促成变化，而只是促成连续性。 (C) 2003 Elsevier Science Inc. 保留所有权利。
We report a longitudinal genetic analysis that combines twins and adoptive and nonadoptive siblings to investigate continuity and change in the etiology of general cognitive ability from infancy through the transition to adolescence. Research in childhood suggests that heritability increases and shared environmental influence decreases, that genetic factors contribute to change as well as continuity, that shared environment contributes entirely to continuity, and that nonshared environment contributes entirely to change. Twins from the Longitudinal Twin Study (LTS; 224 MZ pairs, 189 same-sex DZ pairs at 1 year) and adoptive (genetically unrelated) and nonadoptive (biological) siblings from the Colorado Adoption Project (CAP; 107 and 87 pairs, respectively, at 1 year) were assessed again at 2, 3, 4, 7, 9, and 10 years, and nontwin siblings were also assessed at 12 years. Longitudinal model fitting supported the above hypotheses derived from research in childhood with two exceptions. Nonshared environmental influences contribute to continuity as well as change in middle childhood. The most striking exception is that during the transition to adolescence, genetic factors no longer contribute to change, just to continuity. (C) 2003 Elsevier Science Inc. All rights reserved.