Executive and attention functioning among children in the PANDAS subgroup.
Executive and attention functioning among children in the PANDAS subgroup.
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PANDAS 亚组儿童的执行和注意力功能。
DOI：
10.1080/09297040802186899
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Swedo,SusanE
中科院分区：
文献类型：
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作者：
Hirschtritt,MatthewE;Hammond,ChristopherJ;Luckenbaugh,David;Buhle,Jason;Thurm,AudreyE;Casey,BJ;Swedo,SusanE
过去的研究证据表明，患有强迫症（OCD）和抽动秽语综合征（TS）的成人和儿童会经历微妙的神经心理缺陷。较少了解神经心理功能的儿童和青少年的症状过程符合PANDAS（小儿自身免疫性神经精神疾病与链球菌感染）的强迫症和抽搐亚组。为了提供这些信息，我们对67名被诊断患有强迫症和/或抽搐的儿童和青少年（年龄5-16岁）进行了三项注意力控制测试和两项执行功能测试，这些儿童和青少年的症状过程与PANDAS亚组和98名健康志愿者（HV）的年龄，性别和智商相匹配。在两组的配对比较中，PANDAS受试者在反应抑制测试中的准确性低于HV。此外，在PANDAS组的两步线性回归分析中，临床变量被逐步添加到模型中，并在第二步中添加匹配变量（年龄，性别和智商），智商成为这项任务的预测因子。在同一分析中，ADHD诊断和年龄成为连续性能任务中反应时间的预测因子。通过对PANDAS组的主要精神病诊断进行细分，发现TS或OCD伴抽搐的受试者与对照组相比，反应时间长于仅OCD受试者，这与TS和OCD中的先前研究结果相同。这项研究表明，PANDAS儿童表现出的神经心理学特征与他们的主要精神病诊断相似。
Evidence from past studies indicates that adults and children with Obsessive-Compulsive Disorder (OCD) and Tourette syndrome (TS) experience subtle neuropsychological deficits. Less is known about neuropsychological functioning of children and adolescents with a symptom course consistent with the PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection) subgroup of OCD and tics. To provide such information, we administered three tests of attention control and two of executive function to 67 children and adolescents (ages 5–16) diagnosed with OCD and/or tics and a symptom course consistent with the PANDAS subgroup and 98 healthy volunteers (HV) matched by age, sex, and IQ. In a paired comparison of the two groups, the PANDAS subjects were less accurate than HV in a test of response suppression. Further, in a two-step linear regression analysis of the PANDAS group in which clinical variables were added stepwise into the model and in the second step matching variables (age, sex, and IQ) were added, IQ emerged as a predictor of performance on this task. In the same analysis, ADHD diagnosis and age emerged as predictors of response time in a continuous performance task. Subdividing the PANDAS group by primary psychiatric diagnosis revealed that subjects with TS or OCD with tics exhibited a longer response time compared to controls than subjects with OCD only, replicating previous findings within TS and OCD. This study demonstrates that children with PANDAS exhibit neuropsychological profiles similar to those of their primary psychiatric diagnosis.