Alcohol exposure during development: analysis of effects on female sexual behavior.
Alcohol exposure during development: analysis of effects on female sexual behavior.
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发育过程中的酒精暴露：对女性性行为影响的分析。
DOI：
10.1111/j.1530-0277.2007.00525.x
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Kelly,SandraJ
中科院分区：
文献类型：
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作者：
Gass,JustinT;Jenkins,WilliamJ;Marino,MelissaD;LugoJr,JoaquinN;Kelly,SandraJ
背景：发育过程中的酒精暴露已被证明会改变人类和啮齿动物的各种社会行为。啮齿类动物的性行为已得到很好的表征，并有助于详细研究乙醇影响这种特定社会行为的方式。方法：大鼠在产前和产后早期（ET）期间均接触乙醇。对照组包括仅接受给药程序的大鼠（插管对照）和未治疗的对照（NC）。在成年期（大约出生后第 90 天）评估发情期的完整幼稚雌性大鼠的性行为，并通过 3 室测试装置中各室之间的交叉次数来测量活动。另一项研究检查了所有 3 组中完整的幼稚雌性大鼠对 4 种气味的嗅觉偏好。这 4 种气味分别是完整雄性大鼠占据测试室 1 小时、绝育雄性大鼠占据测试室 1 小时、未绝育雄性大鼠 0.5ml 尿液和绝育雄性大鼠 0.5ml 尿液产生的气味。 结果：与两个对照组相比，ET 雌性大鼠射精后的返回潜伏期缩短。与对照组相比，ET 动物在进行各种形式的雄性行为后，退出百分比呈下降趋势。非实验男性的前凸商数、活动或行为在各组之间没有显着差异。与对照组相比，ET 雌性大鼠对未绝育雄性大鼠的气味偏好降低，与仅 NC 雌性大鼠相比，对性腺切除的雄性大鼠的气味偏好降低。结论：这些数据表明，雌性大鼠在产前和产后期间接触乙醇会改变性动机，并改变雄性大鼠对嗅觉线索和可能的性交线索的处理。
Background:Alcohol exposure during development has been shown to alter a variety of social behaviors in both humans and rodents. Sexual behavior in rodents has been well characterized and lends itself to a detailed investigation of the manner in which ethanol impacts this particular social behavior.Methods:Rats were exposed to ethanol during both the prenatal and early postnatal period (ET). Control groups included rats exposed to the administration procedures alone (intubated‐control) and nontreated controls (NC). Sexual behavior of intact naïve female rats in estrus was assessed in adulthood (approximately postnatal day 90) and activity was measured by the number of crossings between chambers in the 3‐chamber test apparatus. A separate study examined the olfactory preferences for 4 odors by intact naïve female rats in all 3 groups. The 4 odors were the odors resulting from 1 hour of occupation of the test chamber by an intact male, 1 hour of occupation of the test chamber by a gonadectomized male, 0.5 ml of urine from an intact male, and 0.5 ml of urine from a gonadectomized male.Results:ET female rats showed a reduced return latency after ejaculation compared to both control groups. There was a trend toward a reduction in percent exits after all forms of male behavior in the ET animals compared to the control groups. No significant differences across groups were seen in the lordosis quotient, activity, or the behavior of the nonexperimental male. ET female rats showed a reduced preference for the odor from the intact male compared to both control groups and a reduced preference for the odor from the gonadectomized male compared to NC females only.Conclusions:These data suggest that ethanol exposure during the prenatal and postnatal period in females alters sexual motivation and changes the processing of olfactory cues and possibly coital cues from male rats.