Quantitative genetic evidence for trade-off between growth and resistance to oxidative stress in a wild bird
Quantitative genetic evidence for trade-off between growth and resistance to oxidative stress in a wild bird
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DOI：
10.1007/s10682-010-9426-x
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发表时间：
2011-03-01
影响因子：
1.9
通讯作者：
Velando, Alberto
中科院分区：
文献类型：
--
作者：
Kim, Sin-Yeon;Noguera, Jose C.;Velando, Alberto
为什么动物不能以最快的速度生长？最近有人提出，快速生长导致氧化应激导致细胞损伤的积累，影响随后的性能和寿命。因此，快速生长和氧化应激之间的权衡可能会成为生长轨迹演变中的一个重要约束。我们测试这一点，通过检查一个潜在的拮抗多效性之间的增长和血液阻力控制自由基攻击的野生鸟类使用交叉培养设计和强大的定量遗传分析。在黄腿鸥Larus michahellis中，在8天龄时对氧化应激的抵抗力下降与生命的前8天质量增长更快相关，这表明质量增长和氧化应激相关的体细胞维持之间存在权衡。我们发现，鸡的生长和抗氧化应激之间的负遗传相关，支持存在的两个性状之间的遗传权衡。因此，体细胞资源在生长中的投资可能受到表型和遗传水平上对氧化胁迫的抗性的限制。我们的研究结果为野生脊椎动物的生活史和潜在的生理特征之间的潜在遗传权衡提供了第一个证据。未来的研究应该探索生活史性状和其他氧化应激相关性状之间的遗传权衡。
Why do animals not grow at their maximal rates? It has been recently proposed that fast growth leads to the accumulation of cellular damages due to oxidative stress, influencing subsequent performances and life span. Therefore, the trade-off between fast growth and oxidative stress may potentially function as an important constraint in the evolution of growth trajectories. We test this by examining a potential antagonistic pleiotropy between growth and blood resistance to controlled free radical attack in a wild bird using a cross-fostering design and robust quantitative genetic analyses. In the yellow-legged gull Larus michahellis, decreased resistance to oxidative stress at age 8 days was associated with faster growth in mass, across the first 8 days of life, suggesting a trade-off between mass growth and oxidative-stress-related somatic maintenance. We found a negative genetic correlation between chick growth and resistance to oxidative stress, supporting the presence of the genetic trade-off between the two traits. Therefore, investment of somatic resources in growth could be constrained by resistance to oxidative stress in phenotypic and genetic levels. Our results provide first evidence for a potential genetic trade-off between life-history and underlying physiological traits in a wild vertebrate. Future studies should explore genetic trade-offs between life-history traits and other oxidative-stress-related traits.