Cyclooxygenase Expression and Platelet Function in Healthy Dogs Receiving Low-Dose Aspirin
Cyclooxygenase Expression and Platelet Function in Healthy Dogs Receiving Low-Dose Aspirin
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DOI：
10.1111/jvim.12022
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发表时间：
2013-01-01
影响因子：
2.6
通讯作者：
Lunsford, K.
中科院分区：
文献类型：
--
作者：
Dudley, A.;Thomason, J.;Lunsford, K.
低剂量阿司匹林用于预防犬的血栓栓塞并发症，但有些动物对阿司匹林的抗血小板作用无反应（阿司匹林抵抗）。假设/目的小剂量阿司匹林可抑制血小板功能，减少血栓素合成，改变血小板环氧化酶（考克斯）表达。动物24只健康犬。方法重复测量研究。在阿司匹林给药前和给药期间（1 mg/kg，Q24小时PO，10天），评价血小板功能（PFA-100闭合时间、胶原/肾上腺素）、血小板考克斯-1和考克斯-2表达以及尿11-脱氢血栓烷B2（11-dTXB 2）。基于阿司匹林给药后闭合时间的延长，根据阿司匹林反应性将犬分为几类：反应者、无反应者和不一致的反应者。结果低剂量阿司匹林显著增加了闭合时间（第10天为62%，P
Background Low-dose aspirin is used to prevent thromboembolic complications in dogs, but some animals are nonresponsive to the antiplatelet effects of aspirin (aspirin resistance). Hypothesis/Objectives That low-dose aspirin would inhibit platelet function, decrease thromboxane synthesis, and alter platelet cyclooxygenase (COX) expression. Animals Twenty-four healthy dogs. Methods A repeated measures study. Platelet function (PFA-100 closure time, collagen/epinephrine), platelet COX-1 and COX-2 expression, and urine 11-dehydro-thromboxane B2 (11-dTXB2) were evaluated before and during aspirin administration (1mg/kg Q24hours PO, 10days). Based on prolongation of closure times after aspirin administration, dogs were divided into categories according to aspirin responsiveness: responders, nonresponders, and inconsistent responders. Results Low-dose aspirin increased closure times significantly (62% by Day 10, P