Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia
Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia
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DOI：
10.1176/appi.ajp.160.10.1790
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发表时间：
2003-10-01
影响因子：
17.7
通讯作者：
Pantelis, C
中科院分区：
文献类型：
--
作者：
Brewer, WJ;Wood, SJ;Pantelis, C
目的：之前的调查显示，首次服用抗精神病药的患者存在稳定的嗅觉识别缺陷，但尚不清楚这些缺陷是否早于疾病发作。方法：检查了 81 名精神病超高风险患者与 31 名健康对照受试者的嗅觉识别能力。 22 名超高危患者 (27.2%) 后来出现精神病，其中 12 人被诊断患有精神分裂症谱系障碍。 结果：后来发展为精神分裂症谱系障碍的超高危组的嗅觉识别能力存在显着受损，但其他组则没有。结论：这些发现表明，嗅觉识别能力受损是向精神分裂症过渡的病前标志。精神分裂症，但它并不能更普遍地预测精神疾病。
Objective: Previous investigation has revealed stable olfactory identification deficits in neuroleptic-naive patients experiencing a first episode of psychosis, but it is unknown if these deficits predate illness onset.Method: The olfactory identification ability of 81 patients at ultra-high risk for psychosis was examined in relation to that of 31 healthy comparison subjects. Twenty-two of the ultra-high-risk patients (27.2%) later became psychotic, and 12 of these were diagnosed with a schizophrenia spectrum disorder.Results: There was a significant impairment in olfactory identification ability in the ultra-high-risk group that later developed a schizophrenia spectrum disorder but not in any other group.Conclusions: These findings suggest that impairment of olfactory identification is a premorbid marker of transition to schizophrenia, but it is not predictive of psychotic illness more generally.