Associations of cigarette smoking, betel quid chewing and alcohol consumption with high-sensitivity C-reactive protein in early radiographic knee osteoarthritis: a cross-sectional study.
Associations of cigarette smoking, betel quid chewing and alcohol consumption with high-sensitivity C-reactive protein in early radiographic knee osteoarthritis: a cross-sectional study.
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DOI：
10.1136/bmjopen-2015-010763
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发表时间：
2016-03-11
期刊：
影响因子：
2.9
通讯作者：
Lei G
中科院分区：
文献类型：
--
作者：
Zhang Y;Zeng C;Wei J;Li H;Yang T;Yang Y;Deng ZH;Ding X;Lei G
高敏C反应蛋白（hsCRP）可能与骨关节炎（OA）的进展和各种OA相关症状有关。本研究旨在研究早期影像学膝关节OA中吸烟、嚼槟榔和饮酒与hsCRP之间的关系。横断面健康检查调查。这项初步研究是在中国的一个健康检查中心进行的。本横断面研究纳入了936例（656例男性和280例女性）早期影像学膝关节OA患者。根据每日吸烟习惯将吸烟状况分为4个级别：0/天、1-10/天、11-20/天和>20/天。嚼食槟榔与饮酒状况分为“有”与“无”。早期影像学膝关节OA定义为至少一条腿的Kellgren Lawrence（K-L）1级或2级，hsCRP升高评估为≥3.0 mg/L。 在调整了一些潜在的混杂因素后，在多变量模型中观察到吸烟与hsCRP之间存在显著的正相关。第二组中hsCRP升高（≥3.0 mg/L）的多变量校正OR（95% CI） （1-10/天，n=133），第三次（11-20/天，n=59）和最高（>20/天，n=104）吸烟类别为1.54（95% CI 0.91 - 2.61）、1.27（95% CI 0.57 - 2.79）和2.09（95% CI 1.20 - 3.64），与非吸烟者类别（n=640）相比。此外，吸烟与hsCRP升高之间存在正剂量反应关系（趋势p =0.01）。在多变量模型中，没有观察到咀嚼槟榔和饮酒与hsCRP之间的显著相关性。这项研究表明，吸烟与早期放射学膝关节OA患者的血清hsCRP水平呈正相关。然而，鉴于横断面设计的性质，结果需要进一步的前瞻性研究证实。
High-sensitivity C-reactive protein (hsCRP) is possibly related to osteoarthritis (OA) progression and a variety of OA-related symptoms. This study aimed to examine associations between cigarette smoking, betel quid chewing and alcohol consumption and hsCRP in early radiographic knee OA. Cross-sectional health examination survey. This primary study was conducted in a health examination centre in China. 936 (656 men and 280 women) patients with early radiographic knee OA were included in this cross-sectional study. Smoking status was classified into four levels based on daily smoking habit: 0/day, 1–10/day, 11–20/day and >20/day. Betel quid chewing and alcohol consumption status was divided into ‘Yes’ or ‘No’. Early radiographic knee OA was defined as Kellgren Lawrence (K-L) grade 1 or 2 in at least one leg, and elevated hsCRP was assessed as ≥3.0 mg/L. After adjustment for a number of potential confounding factors, a significant positive association between cigarette smoking and hsCRP was observed in the multivariable model. The multivariable-adjusted ORs (95% CI) of elevated hsCRP (≥3.0 mg/L) in the second (1–10/day, n=133), third (11–20/day, n=59) and highest (>20/day, n=104) cigarette smoking categories were 1.54 (95% CI 0.91 to 2.61), 1.27 (95% CI 0.57 to 2.79) and 2.09 (95% CI 1.20 to 3.64), respectively, compared with the non-smoker category (n=640). In addition, there was a positive dose–response relationship between cigarette smoking and elevated hsCRP (p for trend=0.01). No significant associations between betel quid chewing and alcohol consumption and hsCRP were observed in the multivariable model. This study indicated that cigarette smoking was positively associated with serum hsCRP level in patients with early radiographic knee OA. However, in view of the nature of cross-sectional designs, the results need to be confirmed by further prospective studies.