The Impact of Streptozotocin‐Induced Diabetes on the Minimum Alveolar Anesthetic Concentration (MAC) of Inhaled Anesthetics in the Rat
The Impact of Streptozotocin‐Induced Diabetes on the Minimum Alveolar Anesthetic Concentration (MAC) of Inhaled Anesthetics in the Rat
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DOI：
10.1213/00000539-199308000-00022
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发表时间：
1993-08
影响因子：
5.7
通讯作者：
J. E. Brian;Laura Bogan;R. Kennedy;Ernst Seifen
中科院分区：
文献类型：
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作者：
J. E. Brian;Laura Bogan;R. Kennedy;Ernst Seifen
&NA;我们设计了实验来检查胰岛素依赖型糖尿病对挥发性麻醉剂麻醉需求的影响。采用标准尾夹技术测定自主呼吸大鼠中氟烷、安氟醚和异氟醚的最低肺泡麻醉剂浓度。使用三组动物：1）糖尿病大鼠（用链脲佐菌素，50 mg/kg，单剂量，静脉内诱导糖尿病后12周），2）胰岛素治疗的糖尿病大鼠（每天7 U延长胰岛素锌混悬液，皮下注射，从链脲佐菌素治疗后5周开始），和3）对照大鼠。对照动物的最小肺泡麻醉剂浓度值为氟烷1.16 ± 0.02体积%、安氟醚2.25 ± 0.05体积%和异氟醚1.42 ± 0.04体积%。在糖尿病大鼠中，氟烷（0.90 ± 0.06 vol%）、安氟醚（1.85 ± 0.07 vol%）和异氟醚（1.18 ± 0.04 vol%）的最小肺泡麻醉药浓度分别降低了23%、18%和17%。胰岛素治疗恢复了对所有三种麻醉剂的麻醉需求控制水平。来自大鼠模型的这些数据表明，不受控制的糖尿病显著降低了麻醉剂的需求。（Anesth Analg 1993;77：342 - 5）
&NA; We designed experiments to examine the effects of insulin‐dependent diabetes mellitus on the anesthetic requirements for volatile anesthetics. A standard tailclamp technique was used to determine minimum alveolar anesthetic concentrations for halothane, enflurane, and isoflurane in spontaneously breathing rats. Three groups of animals were used: 1) diabetic rats (12 wk after induction of diabetes with streptozotocin, 50 mg/kg, single dose, intravenously), 2) insulintreated (7 U extended insulin zinc suspension per day, subcutaneously, beginning 5 wk after streptozotocin treatment) diabetic rats, and 3) control rats. The minimum alveolar anesthetic concentration values of the control animals were 1.16 ± 0.02 vol% for halothane, 2.25 ± 0.05 vol% for enflurane, and 1.42 ± 0.04 vol% for isoflurane. Minimum alveolar anesthetic concentration was reduced by 23% for halothane (0.90 ± 0.06 vol%), by 18% for enflurane (1.85 ± 0.07 vol%), and by 17% for isoflurane (1.18 ± 0.04 vol%) in diabetic rats. Insulin treatment restored the anesthetic requirement to control levels for all three anesthetics. These data from the rat model indicate that uncontrolled diabetes lowers anesthetic requirements significantly. (Anesth Analg 1993;77:342‐5)