BLACK-WHITE DIFFERENCES IN SERUM COTININE LEVELS AMONG PREGNANT-WOMEN AND SUBSEQUENT EFFECTS ON INFANT BIRTH-WEIGHT
BLACK-WHITE DIFFERENCES IN SERUM COTININE LEVELS AMONG PREGNANT-WOMEN AND SUBSEQUENT EFFECTS ON INFANT BIRTH-WEIGHT
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DOI：
10.2105/ajph.84.9.1439
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发表时间：
1994-09-01
影响因子：
12.7
通讯作者：
CHRISTIANSON, RE
中科院分区：
文献类型：
--
作者：
ENGLISH, PB;ESKENAZI, B;CHRISTIANSON, RE
目标.即使在自我报告的香烟剂量得到控制后，也发现黑人吸烟者的血清可替宁（尼古丁的代谢产物）水平高于白色吸烟者。目前尚不清楚黑人孕妇吸烟者中较高的可替宁水平是否会增加分娩出生体重减轻婴儿的风险。我们分析了374名黑人和829名白色妇女的血清可替宁水平，这些妇女在怀孕期间吸烟，并在1964年4月至1967年4月期间分娩。可替宁和出生体重之间的关系的种族差异进行了检查。吸烟后，黑人吸烟者的可替宁水平高出27.4 ng/mL，并控制了混杂变量。在每种剂量下，黑人的可替宁水平都高于白人。每纳克每毫升可替宁的出生体重下降率没有显着的种族差异。我们的研究结果证实了以前的研究显示，黑人吸烟者比白色吸烟者在每种吸烟剂量下的可替宁水平更高。由于可替宁导致的出生体重下降率没有差异，我们的研究结果表明，黑人吸烟对出生体重的影响可能大于白人。
Objectives. Higher levels of serum cotinine (a metabolite of nicotine) have been found in Black smokers than in White smokers even after self-reported cigarette dose was controlled. It is unknown whether higher cotinine levels in Black pregnant smokers may increase the risk of delivering an infant of reduced birthweight.Methods. We analyzed serum cotinine levels of 374 Black and 829 White women who smoked during pregnancy and who delivered between April 1964 and April 1967. Racial differences in the relationship between cotinine and birthweight were examined.Results. Cotinine levels were 27.4 ng/mL higher in Black smokers after cigarette dose and confounding variables were controlled. Blacks had higher cotinine levels than Whites at each dose. No significant racial differences in the rate of decrease in birthweight per nanogram of cotinine per milliliter were found.Conclusions. Our results confirm previous research showing higher cotinine levels at each smoking dose in Black smokers than in White smokers. Because there was no difference in the rate of decrease in birthweight due to cotinine, our results suggest that cigarette smoking among Blacks may have a greater effect on birthweight than it does among Whites.