Predictors and clinical complications associated with antiphospholipid antibodies in sickle cell disease.
Predictors and clinical complications associated with antiphospholipid antibodies in sickle cell disease.
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DOI：
10.1002/jha2.643
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发表时间：
2023-02
期刊：
影响因子：
--
通讯作者：
Saraf, Santosh L
中科院分区：
文献类型：
--
作者：
Rivera, Claudia Rodriguez;Srisuwananukorn, Andrew;Bajwa, Rizma Jalees;Gordeuk, Victor R;Rauch, Joyce;Levine, Jerrold S;Saraf, Santosh L
尽管在镰状细胞病（SCD）患者的一些队列中观察到抗磷脂自身抗体（aPL）的较高患病率，但aPL发展及其相关并发症的临床危险因素尚不清楚。在一项对63例SCD患者的回顾性研究中，较低的血红蛋白浓度和较高的白细胞计数与aPL升高独立相关。aPL升高的SCD患者妊娠并发症（≥3次流产、早产、先兆子痫）和静脉血栓事件增加。我们的研究结果表明，SCD可能倾向于aPL的产生，而aPL本身可能有助于SCD的血管病变。对SCD患者进行aPL的前瞻性检测是有必要的。
Although a higher prevalence of antiphospholipid autoantibodies (aPL) has been observed in some cohorts of sickle cell disease (SCD) patients, the clinical risk factors for the development of aPL and its associated complications remain unclear. In a retrospective study of 63 SCD patients, a lower hemoglobin concentration and higher white blood cell count were independently associated with an elevated aPL. SCD patients with elevated aPL had increased pregnancy complications (≥3 miscarriages, preterm delivery, pre‐eclampsia) and venous thrombotic events. Our findings suggest that SCD may predispose to the generation of aPL and that aPL itself may contribute to the vasculopathy of SCD. Prospective testing for aPL is warranted in patients with SCD.
Haptoglobin 1等位基因预测镰状细胞疾病中较高的血清Haptoglobin浓度和较低的多器官衰竭风险。
影响因子：
7.5
作者：
Ruiz, Maria A.;Shah, Binal N.;Ren, Guohui;Hussain, Faiz;Njoku, Franklin;Machado, Roberto F.;Gordeuk, Victor R.;Saraf, Santosh L.
通讯作者：
Saraf, Santosh L.