Frequency Dependence of Ultrasound Neurostimulation in the Mouse Brain.
Frequency Dependence of Ultrasound Neurostimulation in the Mouse Brain.
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DOI：
10.1016/j.ultrasmedbio.2016.02.012
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发表时间：
2016-07
影响因子：
2.9
通讯作者：
Pauly KB
中科院分区：
文献类型：
--
作者：
Ye PP;Brown JR;Pauly KB
超声神经调节有望成为中枢神经系统神经调节的非侵入性技术。然而，关于如何将该技术转化为有用的技术，包括超声频率的影响，还有很多问题有待确定。先前的研究已经证明了使用小于1 MHz的频率进行体内神经调节，并且具有使用较低频率改善疗效的趋势。然而，使用更高的频率可以提高超声空间分辨率。我们研究了在低于和高于1 MHz的各种频率下小鼠的超声神经调节作用，发现高达2.9 MHz的频率仍然可以有效地产生运动反应，但也证实随着频率的增加，声处理需要更大的强度才能达到同等的效果。我们认为，我们的研究结果提供的证据，有利于粒子位移或空化为基础的机制的现象，超声神经调制。
Ultrasound neuromodulation holds promise as a non-invasive technique for neuromodulation of the central nervous system. However, much remains to be determined about how the technique can be transformed into a useful technology, including the effect of ultrasound frequency. Previous studies have demonstrated neuromodulation in vivo using frequencies less than 1 MHz, with a trend towards improved efficacy with lower frequency. However, using higher frequencies could offer improved ultrasound spatial resolution. We investigate the ultrasound neuromodulation effects in mice at various frequencies both below and above 1 MHz and find that frequencies up to 2.9 MHz can still be effective for generating motor responses, but also confirm that as frequency increases, sonications require significantly more intensity to achieve equivalent efficacy. We argue that our results provide evidence that favors either a particle displacement or a cavitation-based mechanism for the phenomenon of ultrasound neuromodulation.