Non-invasive assessment of language dominance with near-infrared spectroscopic mapping
Non-invasive assessment of language dominance with near-infrared spectroscopic mapping
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DOI：
10.1016/s0304-3940(98)00754-x
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发表时间：
1998-10-30
影响因子：
2.5
通讯作者：
Mayanagi, Y
中科院分区：
文献类型：
--
作者：
Watanabe, E;Maki, A;Mayanagi, Y
大脑半球对语言的优势通常通过WADS测试来评估，在WADS测试中，将异巴比妥注射到颈动脉中。最近，正电子发射断层扫描和功能磁共振已被用作该方法的无创性替代方法。我们应用24通道近红外光谱地形图(NIRS)作为另一种非侵入性方法来检测语言任务中单侧大脑的激活。我们使用了11名健康志愿者和6名顽固性癫痫患者。对17名S进行词汇生成任务，随后对60名S进行消退/静息期。在健康志愿者中，额叶下部在婴儿期与利手相对的一侧被激活。在癫痫病例中，激活侧与Wada测验所确定的优势一致。我们的结果表明，近红外光谱是一种可行的非侵入性替代WADA试验。(C)1998爱思唯尔爱尔兰科学有限公司。保留所有权利。
Hemispheric dominance for language is usually assessed by means of the Wads test where amobarbital is injected into the carotid artery. Recently, positron emission tomography and functional MRI have been used as non-invasive alternatives to this method. We have applied 24-channel near-infrared spectroscopic topography (NIRS) as another non-invasive method to detect the unilateral cerebral activation during a language task. We used 11 healthy volunteers and six patients with intractable epilepsy. A word-generation task was applied for 17 s, followed by an extinction/resting period of 60 s. In healthy volunteers, the inferior frontal region was activated on the side opposite to the subject's handedness in infancy. In the epilepsy cases, the activated side agreed with the dominance determined by the Wada test. Our results demonstrate that NIRS is a feasible noninvasive alternative to the Wada test. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.