Age-related changes in the default mode network are more advanced in Alzheimer disease
Age-related changes in the default mode network are more advanced in Alzheimer disease
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DOI：
10.1212/wnl.0b013e318233b33d
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发表时间：
2011-10-01
期刊：
影响因子：
9.9
通讯作者：
Jack, C. R., Jr.
中科院分区：
文献类型：
--
作者：
Jones, D. T.;Machulda, M. M.;Jack, C. R., Jr.
目的：研究认知正常的老年人群和阿尔茨海默病(AD)患者与年龄、性别和教育程度相匹配的对照组的年龄相关默认模式网络(DMN)连接性。方法：我们用独立成分分析和基于种子的分析来分析无任务fMRI数据，以识别前后部DMN。我们调查了341名认知正常受试者的年龄相关性连接性变化。然后，我们对28例AD患者和56例认知正常的APOE epsilon 4等位基因非携带者进行了年龄、教育程度和性别匹配的比较。结果：前侧DMN表现出与年龄相关的前叶连通性增加和减少，而后部DMN则主要表现为与年龄相关的连通性下降。与匹配的认知正常对照组相比，AD患者表现出上述年龄相关变化的加速模式，只是额叶连接性的下降没有达到统计学意义。这些变化在萎缩矫正后仍存在，并与认知能力相关。结论：本研究结果表明，与对照组相比，AD患者的DMN异常表现为加速老化的连接性模式。神经病学(R)2011；77：1524-1531
Objective: To investigate age-related default mode network (DMN) connectivity in a large cognitively normal elderly cohort and in patients with Alzheimer disease (AD) compared with age-, gender-, and education-matched controls.Methods: We analyzed task-free-fMRI data with both independent component analysis and seed-based analysis to identify anterior and posterior DMNs. We investigated age-related changes in connectivity in a sample of 341 cognitively normal subjects. We then compared 28 patients with AD with 56 cognitively normal noncarriers of the APOE epsilon 4 allele matched for age, education, and gender.Results: The anterior DMN shows age-associated increases and decreases in fontal lobe connectivity, whereas the posterior DMN shows mainly age-associated declines in connectivity throughout. Relative to matched cognitively normal controls, subjects with AD display an accelerated pattern of the age-associated changes described above, except that the declines in frontal lobe connectivity did not reach statistical significance. These changes survive atrophy correction and are correlated with cognitive performance.Conclusions: The results of this study indicate that the DMN abnormalities observed in patients with AD represent an accelerated aging pattern of connectivity compared with matched controls. Neurology (R) 2011;77:1524-1531