Defining the phenotype of schizophrenia: Cognitive dysmetria and its neural mechanisms
Defining the phenotype of schizophrenia: Cognitive dysmetria and its neural mechanisms
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DOI：
10.1016/s0006-3223(99)00152-3
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发表时间：
1999-10-01
影响因子：
10.6
通讯作者：
Flaum, L
中科院分区：
文献类型：
--
作者：
Andreasen, NC;Nopoulos, P;Flaum, L
所有关于精神分裂症的研究都取决于选择正确的表型来定义要研究的样本。表型的定义因该疾病没有客观标记这一事实而变得复杂。此外，症状多种多样，导致一些人提出该疾病是异质的，而不是单一的疾病或综合征。本文探讨了另一种可能性。它提出精神分裂症可能是一种由共同的病理生理学（一种神经发育机制）联系在一起的单一疾病，导致神经回路的错误连接综合症。探索了特定回路中断的证据：皮质-丘脑-小脑-皮质回路（CCTCC），表明该回路的中断会导致同步性或心理过程的平稳协调受损，当同步时。受损，患者患有认知障碍，这种基本认知过程的受损定义了精神分裂症的表型并产生其多样性的症状。生物精神病学 1999；46：908-920 (C) 1999 生物精神病学协会。
All research on schizophrenia depends on selecting the correct phenotype to define the sample to be studied. Definition of the phenotype is complicated by the fact that there are no objective markers for the disorder Further, the symptoms are diverse, leading some to propose that the disorder is heterogeneous and nor a single disorder or syndrome. This article explores an alternative possibility. It proposes that schizophrenia may be a single disorder linked by a common pathophysiology (a neurodevelopmental mechanism), which leads to a misconnection syndrome of neural circuitry. Evidence for disruption in a specific circuit is explored: the cortical-thalamic-cerebellar-cortical circuit (CCTCC), It is suggested that a disruption in this circuit leads to an impairment in synchrony, or the smooth coordination of mental processes, When synchrony. is impaired, the patient suffers from a cognitive dysmetria, and the impairment in this basic cognitive process defines the phenotype of schizophrenia and produces its diversity of symptoms. Biol Psychiatry 1999;46:908-920 (C) 1999 Society of Biological Psychiatry.