The mechanism of self-disinfection of the human skin and its appendages
The mechanism of self-disinfection of the human skin and its appendages
复制标题
DOI：
10.1017/s0022172400035373
复制
发表时间：
1942-04-01
影响因子：
--
通讯作者：
Burtenshaw, JML
中科院分区：
文献类型：
--
作者：
Burtenshaw, JML
盐水、乙醚和酒精制剂。研究了皮肤刮屑、头发、耵聍和指甲对链球菌和其他生物体的杀菌作用。 pH 值较低时，作用更大。除一名例外外，数人皮肤、头发等的乙醚提取物对 4 种链球菌有效。链球菌散布在手掌皮肤的清洗和未清洗区域，并且从乙醚清洗区域回收的微生物多于未清洗或盐水处理的皮肤。溶于乙醚的物质对溶血链球菌、链球菌有一定的杀菌作用。草绿色和白喉梭菌，对链球菌的活性不同。对肺炎链球菌和葡萄球菌无作用，对伤寒埃伯氏菌和大肠杆菌无作用。制备了几种毛发提取物。杀菌作用被认为是由于长链脂肪酸和肥皂。半胱氨酸和血液的抑制作用以及紫外线的影响。研究了光对链球菌的杀灭作用。经验。还使用某些有机酸和溶菌酶进行了实验。研究和讨论了皮肤脂肪的其他特性。列表式的exptl。结果附在报告后。
Saline, ether and alcoholic prepns. of skin scrapings, hair, cerumen and nails were studied for their bactericidal action on streptococci and other organisms. The action was greater with a low pH. Ether extracts of skin, hair, etc. of several persons, with one exception, were effective against 4 strains of streptococci. Streptococci were spread on washed and unwashed areas of palmar skin and more organisms were recovered from ether-washed areas than from unwashed or saline treated skin. The ether-soluble substance had definite bactericidal action on Streptococcus haemolyticus, Str. viridans and Clostridium diphtheriae, variable activity against Str. pneumoniae and staphylococci and no effect on Eberthella typhosa and Escherichia colt. Several kinds of extracts of hair were prepd. and the bactericidal action was considered to be due to long chain fatty acids and soaps. The inhibitory action of cystein and blood and the influence of u.-v. light on streptococcocidal effects were investigated. Expts. were also performed with certain organic acids and with lysozyme. Other properties of the skin fats were studied and discussed. The tabulated exptl. results are appended to the report.