Mechanotransduction in cancer stem cells
Mechanotransduction in cancer stem cells
复制标题
癌症干细胞中的力转导
DOI：
10.1002/cbin.10111
复制
发表时间：
2013-09-01
影响因子：
3.9
通讯作者：
Li, Juan
中科院分区：
文献类型：
--
作者：
Hao, Jin;Zhang, Yueling;Li, Juan
大约十年前出现的癌症干细胞(CSC)概念提出，肿瘤的生长是由高度恶性的细胞亚群维持的。这些细胞被称为CSCs，能够广泛的自我更新，有助于转移和治疗耐药。因此，应该开发针对CSCs的治疗策略来改善癌症患者的预后。最近的进展强调了细胞外基质的物理性质和癌细胞中的机械转导途径在癌症发展过程中的重要性。另一方面，作为FAK/PI3K/Akt上游信号的CXCR1在CSCs中的意义已被揭示。FAK/PI3K/Akt是机械信号转导通路中的关键信号调节因子。因此，通过抑制FAK/PI3K/Akt，机械转导可能成为肿瘤干细胞的新靶点，有望成为治疗肿瘤的新途径。
The cancer stem cell (CSC) concept, which arose about a decade ago, proposes that tumor growth is sustained by a subpopulation of highly malignant cells. These cells, termed CSCs, are capable of extensive self-renewal that contributes to metastasis and treatment resistance. Therefore, therapeutic strategies that target CSCs should be developed for improving outcomes of cancer patients. Recent progress has highlighted the importance of physical properties of the extracellular matrix and mechanotransduction pathway in cancer cells during cancer development. On the other hand, the significance of CXCR1, an upstream signal of FAK/PI3K/Akt has been revealed in CSCs. FAK/PI3K/Akt is a key signal mediator in mechanotransduction pathway. Therefore, mechanotransduction could be a new target for CSCs, and would be an innovative way to treat cancer by inhibiting FAK/PI3K/Akt.