Heparin-released extracellular superoxide dismutase is reduced in patients with coronary artery atherosclerosis
Heparin-released extracellular superoxide dismutase is reduced in patients with coronary artery atherosclerosis
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DOI：
10.1016/j.atherosclerosis.2005.08.028
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发表时间：
2006-07-01
期刊：
影响因子：
5.3
通讯作者：
Nakashima, Yasuhide
中科院分区：
文献类型：
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作者：
Tasaki, Hiromi;Yamashita, Kazuhito;Nakashima, Yasuhide
目的：我们研究了肝素释放的细胞外超氧化物歧化酶（EC-SOD），这是一种抗氧化酶，是否与冠状动脉disease（CAD）有关。方法和结果：EC-SOD在315例患者的基础和肝素注射后的血浆中测定。肝素释放的EC-SOD计算为两个值之间的差。排除突变型EC-SOD组（n = 27：8.6%）后，根据血管造影结果将288例患者分为3组：正常冠状动脉（正常组; n = 63），动脉粥样硬化无显著狭窄（轻度动脉粥样硬化组; n = 36），和显著狭窄（动脉粥样硬化组; n = 189）。尽管三组之间的基础值相似，但动脉粥样硬化组肝素释放的EC-SOD水平（131.0 +/- 42.8 ng/ml，p = 0.0003）显著低于正常组（156.9 +/- 66.2 ng/ml）。Logistic回归分析显示肝素释放的EC-SOD是CAD的独立危险因素。冠状动脉评分与肝素释放EC-SOD呈显著相关。至于影响肝素释放的EC-SOD水平的因素，高密度脂蛋白胆固醇水平和年龄呈正相关。结论：结果表明，肝素释放的EC-SOD显着降低CAD和组织结合的位置，这种酶可能是重要的抗氧化功能。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Objectives: We studied whether the amount of heparin-released extracellular superoxide dismutase (EC-SOD), which is an antioxidative enzyme, is associated with coronary artery disease (CAD).Methods and results: EC-SOD was measured in plasma at basal and at post-heparin injection in 315 patients. Heparin-released EC-SOD was calculated as the difference between the two values. After exclusion of a mutant EC-SOD group (n = 27:8.6%), 288 patients were divided into three groups by angiographic findings; those with normal coronary (the normal group; n = 63), those with atherosclerosis without significant stenosis (the mild atherosclerosis group; n = 36), and those with significant stenosis (the atherosclerosis group; n = 189). Although the basal values were similar among the three groups, heparin-released EC-SOD levels were significantly lower in the atherosclerosis group (131.0 +/- 42.8 ng/ml, p = 0.0003) than in the normal group (156.9 +/- 66.2 ng/ml). Moreover, logistic analysis revealed that heparin-released EC-SOD independently contributed to CAD. The coronary score showed a significant correlation with heparin-released EC-SOD. As for factors affecting the level of heparin-released EC-SOD, the level of high-density lipoprotein cholesterol and age showed a positive correlation.Conclusions: The results suggest that heparin-released EC-SOD is significantly reduced in CAD and that the tissue-bound location of this enzyme might be important for antioxidative function. (c) 2005 Elsevier Ireland Ltd. All rights reserved.