Covariation of synaptonemal complex length and mammalian meiotic exchange rates
Covariation of synaptonemal complex length and mammalian meiotic exchange rates
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DOI：
10.1126/science.1071220
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发表时间：
2002-06-21
期刊：
影响因子：
56.9
通讯作者：
Hassold, TJ
中科院分区：
文献类型：
--
作者：
Lynn, A;Koehler, KE;Hassold, TJ
位点之间的重组分析（连锁分析）一直是人类遗传学研究的基石，使研究人员能够定位并最终识别遗传位点。然而，尽管做出了这些努力，但人们对人类生殖细胞减数分裂交换的模式或控制这些模式的机制知之甚少。使用最近开发的免疫荧光方法来检查人类精母细胞的交换，我们发现个体内部和个体之间的重组率存在显着差异。随后的分析表明，在人类和小鼠中，这种变异与联会复合体长度的差异有关。因此，至少在哺乳动物中，物理结构（联会复合体）反映的是遗传距离，而不是物理距离。
Analysis of recombination between loci (linkage analysis) has been a cornerstone of human genetic research, enabling investigators to localize and, ultimately, identify genetic loci. However, despite these efforts little is known about patterns of meiotic exchange in human germ cells or the mechanisms that control these patterns. Using recently developed immuno fluorescence methodology to examine exchanges in human spermatocytes, we have identified remarkable variation in the rate of recombination within and among individuals. Subsequent analyses indicate that, in humans and mice, this variation is linked to differences in the length of the synaptonemal complex. Thus, at least in mammals, a physical structure, the synaptonemal complex, reflects genetic rather than physical distance.