Modality-specific cognitive function of medial and lateral human Brodmann area 6
Modality-specific cognitive function of medial and lateral human Brodmann area 6
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DOI：
10.1523/jneurosci.4324-04.2005
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发表时间：
2005-01-12
影响因子：
5.3
通讯作者：
Sadato, N
中科院分区：
文献类型：
--
作者：
Tanaka, S;Honda, M;Sadato, N
尽管人类布罗德曼 6 区 (BA6)，一个传统的“运动”区域，在涉及各种认知操作的高级运动控制过程中很活跃，但 BA6 在认知领域的功能专业化基本上是未知的。此外，其在认知中的功能相关性也受到质疑，因为认知任务期间 BA6 的大脑活动经常被解释为伴随的潜在运动过程。因此，我们使用功能磁共振成像（fMRI）和重复经颅磁刺激（rTMS）检查了人类BA6在非运动认知功能中的结构-功能关系及其功能相关性。受试者执行心理操作（MO）任务，在任务中他们连续更新言语和空间心理表征（MO-v 和 MO-s）。在fMRI实验中，MO-v中内侧BA6的活性增加更多，而MO-s中两个半球外侧BA6的活性增加更多。对内侧 BA6 的低频 rTMS 仅扰乱 MO-v 的性能，而对两个半球的外侧 BA6 的 rTMS 仅扰乱 MO-s。因此，收敛结果表明功能双重解离，其中内侧 BA6 在更新言语信息中发挥关键作用，而外侧 BA6 在更新空间信息中发挥作用。本研究提供了人类 BA6 内模态特异性认知功能的直接生理证据。
Despite the fact that human Brodmann area 6 (BA6), a traditional "motor" area, is active during higher motor control involving various cognitive operations, the functional specialization within BA6 in the cognitive domain is essentially unknown. Furthermore, its functional relevance in cognition has been questioned because brain activity in BA6 during cognitive tasks has often been explained away as a concomitant, latent motor process. Therefore, we examined the structural-functional relationship of human BA6 in nonmotor cognitive functions and its functional relevance using both functional magnetic resonance imaging ( fMRI) and repetitive transcranial magnetic stimulation (rTMS). Subjects performed mental-operation ( MO) tasks in which they serially updated verbal and spatial mental representations (MO-v and MO-s). In the fMRI experiments, activity in the medial BA6 was more increased in MO-v, whereas the activity in the lateral BA6 in both hemispheres was more in MO-s. Low-frequency rTMS to the medial BA6 disrupted only the performance of MO-v, whereas rTMS to the lateral BA6 in both hemispheres disrupted only MO-s. Hence the converging results demonstrate a functional double dissociation in which medial BA6 has a critical role in updating verbal information and lateral BA6 has a role in updating spatial information. The present study provides direct physiological evidence of modality-specific cognitive function within human BA6.