Synthesis of (E)-Quinoxalinone Oximes through a Multicomponent Reaction under Mild Conditions
Synthesis of (E)-Quinoxalinone Oximes through a Multicomponent Reaction under Mild Conditions
复制标题
温和条件下多组分反应合成(E)-喹喔啉酮肟
DOI：
10.1021/acs.orglett.0c03918
复制
发表时间：
2021-01-01
期刊：
影响因子：
5.2
通讯作者：
Zhang, Pengfei
中科院分区：
文献类型：
--
作者：
Xu, Jun;Yang, Huiyong;Zhang, Pengfei
本文报道了一种在温和条件下通过多组分反应合成(E)-喹啉酮肟的克级新方法。这种转变是在无过渡金属的条件下进行的，通过再结晶获得了中等到良好产量的(E)-肟。我们的方法证明了曼尼奇型反应和自由基偶联的成功结合，为合成具有潜在生物活性的喹诺沙林酮分子提供了一种绿色实用的方法。
Herein, a novel method for the gram-scale synthesis of (E)-quinoxalinone oximes through a multicomponent reaction under mild conditions is described. Such a transformation was performed under transition-metal-free conditions, affording (E)-oximes in a moderate-to-good yield through recrystallization. Our methodology demonstrates a successful combination of a Mannich-type reaction and radical coupling, providing a green and practical approach for the synthesis of potentially bioactive quinoxalinone-containing molecules.